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Acute effects of interrupting prolonged sitting on vascular function in type 2 diabetes

Citation

Taylor, FC and Dunstan, DW and Homer, AR and Dempsey, PC and Kingwell, BA and Climie, RE and Owen, N and Cohen, ND and Larsen, RN and Grace, M and Eikelis, N and Wheeler, MJ and Townsend, MK and Maniar, N and Green, DJ, Acute effects of interrupting prolonged sitting on vascular function in type 2 diabetes, American Journal of Physiology. Heart and Circulatory Physiology, 320, (1) pp. H393-H403. ISSN 1522-1539 (2021) [Refereed Article]


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Copyright 2021 the American Physiological Society

DOI: doi:10.1152/ajpheart.00422.2020

Abstract

In healthy and overweight/obese adults, interrupting prolonged sitting with activity bouts mitigates impairment in vascular function. However, it is unknown whether these benefits extend to those with type 2 diabetes (T2D), nor whether an optimal frequency of activity interruptions exist. We examined the acute effects on vascular function in T2D of interrupting prolonged sitting with simple resistance activities (SRA) at different frequencies. In a randomized crossover trial, 24 adults with T2D (35−70 yr) completed three 7-h conditions: 1) uninterrupted sitting (SIT), 2) sitting with 3-min bouts of SRA every 30 min (SRA3), and 3) sitting with 6 min bouts of SRA every 60 min (SRA6). Femoral artery flow-mediated dilation (FMD), resting shear rate, blood flow, and endothelin-1 were measured at 0, 1, 3.5, 4.5, and 6.57 h. Mean femoral artery FMD over 7 h was significantly higher in SRA3 (4.1  0.3%) compared with SIT (3.7  0.3%, P = 0.04) but not in SRA6. Mean resting femoral shear rate over 7 h was increased significantly for SRA3 (45.3  4.1/s, P < 0.001) and SRA6 (46.2  4.1/s, P < 0.001) relative to SIT (33.1  4.1/s). Endothelin-1 concentrations were not statistically different between conditions. Interrupting sitting with activity breaks every 30 min, but not 60 min, significantly increased mean femoral artery FMD over 7 h, relative to SIT. Our findings suggest that more frequent and shorter breaks may be more beneficial than longer, less frequent breaks for vascular health in those with T2D.

Item Details

Item Type:Refereed Article
Keywords:type 2 diabetes, vascular ageing, arteries, blood flow, sedentary behavior
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Cardiology (incl. cardiovascular diseases)
Objective Division:Health
Objective Group:Clinical health
Objective Field:Prevention of human diseases and conditions
UTAS Author:Climie, RE (Dr Rachel Climie)
ID Code:149549
Year Published:2021
Web of Science® Times Cited:10
Deposited By:Menzies Institute for Medical Research
Deposited On:2022-04-04
Last Modified:2022-05-12
Downloads:4 View Download Statistics

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