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Cardiovascular health at age five years: distribution, determinants and association with neurodevelopment

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Climie, RE and Tafflet, M and van Stolen, T and de Lauzon-Guillain, Blandine and Bernard, JY and Dargent-Molina, P and Plancoulaine, S and Lioret, S and Jouven, X and Charles, MA and Heude, B and Empana, JP, Cardiovascular health at age five years: distribution, determinants and association with neurodevelopment, Frontiers in Pediatrics ISSN 2296-2360 (2022) [Refereed Article]


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Copyright 2022 Climie, Tafflet, Sloten, Lauzon-Guillain, Bernard, Dargent- Molina, Plancoulaine, Lioret, Jouven, Charles, Heude and Empana. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) License (https://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

DOI: doi:10.3389/fped.2022.827525

Abstract

Background Early childhood may represent an opportune time to commence primordial prevention of cardiovascular disease (CVD, i.e. prevention of risk factors onset) but epidemiological evidence is scarce. We aimed to examine the distribution and parental and early life determinants of ideal cardiovascular health (CVH) in children up to five years and to compare the level of cognitive development between children with and without ideal CVH at age five.

Methods Using data from the EDEN study, a French population-based mother-child cohort study, CVH was examined in children at five years of age based on the American Heart Association CVH metrics (ideal body mass index, physical activity, diet, blood pressure, cholesterol and glucose levels and passive smoking, considered in sensitivity analysis only). Children were categorized as having ideal (5-6 ideal metrics) or non-ideal CVH (<5 ideal metrics). Intelligence quotient (IQ) at age five was assessed using the French version of the Wechsler Preschool and Primary Scale of Intelligence.

Results Among the 566 children (55% boys), only 34% had ideal CVH. In fully adjusted logistic regression, boys compared to girls (OR=1.77, 95% CI1.13-2.78), children with intermediate (1.77, 1.05-2.98) or ideal (2.58, 1.38-4.82) behavioral CVH at age three and children who spent <30 minutes per day watching television (1.91, 1.09-3.34) at age three were more likely to have ideal CVH at age five. At age five, there was a significant 2.98-point difference (95% CI 0.64-5.32) in IQ between children with, compared to those without, ideal biological CVH after adjusting for confounders.

ConclusionThis study highlights that only a third of children aged five had ideal CVH, identified modifiable determinants of ideal CVH and is suggestive of an association between CVH and neurodevelopment at a young age.

Item Details

Item Type:Refereed Article
Keywords:childhood, determinants, neurodevelopment, primordial prevention, cardiovascular health
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Cardiology (incl. cardiovascular diseases)
Objective Division:Health
Objective Group:Clinical health
Objective Field:Prevention of human diseases and conditions
UTAS Author:Climie, RE (Dr Rachel Climie)
ID Code:149528
Year Published:2022
Web of Science® Times Cited:1
Deposited By:Menzies Institute for Medical Research
Deposited On:2022-04-04
Last Modified:2022-05-13
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