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Comparison of 6-month outcomes of COVID-19 vs Non-COVID-19 survivors of critical illness


Hodgson, CL and Higgins, AM and Bailey, MJ and Mather, AM and Beach, L and Bellomo, R and Bissett, B and Boden, IJ and Bradley, S and Burrell, A and Cooper, DJ and Fulcher, BJ and Haines, KJ and Hodgson, IT and Hopkins, J and Jones, AYM and Lane, S and Lawrence, D and van der Lee, L and Liacos, J and Linke, NJ and Marques Gomes, L and Nickels, M and Ntoumenopoulos, G and Myles, PS and Patman, S and Paton, M and Pound, G and Rai, S and Rix, A and Rollinson, TC and Tipping, CJ and Thomas, P and Trapani, T and Udy, AA and Whitehead, C and Anderson, S and Neto, AS and The COVID-Recovery Study Investigators and the ANZICS Clinical Trials Group, Comparison of 6-month outcomes of COVID-19 vs Non-COVID-19 survivors of critical illness, American Journal of Respiratory and Critical Care Medicine ISSN 1073-449X (2022) [Refereed Article]

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Available from 03 March 2023

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Copyright 2022 American Thoracic Society

DOI: doi:10.1164/rccm.202110-2335OC


Rationale: The outcomes of survivors of critical illness due to COVID-19 compared to non-COVID are yet to be established. Objective: We aimed to compare new disability at 6-months in mechanically ventilated patients admitted to Australian intensive care units (ICUs) with COVID-19 compared to non-COVID-19. Methods: We included COVID-19 and non-COVID-19 critically ill patients from two prospective observational studies. Patients were eligible if they were adult (age ≥18 years) with over 24 hours of mechanical ventilation. Measurements: Demographic, intervention and hospital outcome data were obtained from electronic medical records. Survivors were contacted by telephone for functional outcomes with trained outcome assessors using the World Health Organization Disability Assessment Schedule 2.0. Main Results: Between 6 March 2020 and 21 April 2021, 120 critically ill patients with COVID-19 and between August 2017 and January 2019, 199 critically ill patients without COVID-19 fulfilled the inclusion criteria. Patients with COVID-19 were older (62 (55-71) vs 58 (44-69), p=0.019) with a lower APACHE II (17 (13-20) vs 19 (15-23), p=0.011). While duration of ventilation was longer in patients with COVID-19 compared to without COVID-19 (12 days (5-19) vs 4.8 (2.3-8.8), p <0.001), 180-day mortality was similar between the groups (39/120 (32.5%) vs 70/199 (35.2%), p=0.715). The incidence of death or new disability at 180 days was similar (58/93 (62.4%) versus 99/150 (66/0%), p=0.583). Conclusion: At 6-months there was no difference in new disability for patients requiring mechanical ventilation for acute respiratory failure due to COVID-19 compared to non-COVID-19. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (

Item Details

Item Type:Refereed Article
Keywords:COVID-19, long term outcomes, critical illness, intensive care, SARS-CoV-2, recovery
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Infectious diseases
Objective Division:Health
Objective Group:Provision of health and support services
Objective Field:Health surveillance
UTAS Author:Boden, IJ (Dr Ianthe Boden)
ID Code:149498
Year Published:2022
Web of Science® Times Cited:3
Deposited By:Health Sciences
Deposited On:2022-04-01
Last Modified:2022-05-06

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