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Biosynthetic pathways of triterpenoids and strategies to improve their biosynthetic efficiency


Noushahi, HA and Khan, AH and Noushahi, UF and Hussain, M and Javed, T and Zafar, M and Batool, M and Ahmed, U and Liu, K and Harrison, MT and SAud, S and Fahad, S and Shu, S, Biosynthetic pathways of triterpenoids and strategies to improve their biosynthetic efficiency, Plant Growth Regulation ISSN 0167-6903 (2022) [Refereed Article]

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DOI: doi:10.1007/s10725-022-00818-9


"Triterpenoids" can be considered natural products derived from the cyclization of squalene, yielding 3-deoxytriterpenes (hydrocarbons) or 3-hydroxytriterpenes. Triterpenoids are metabolites of these two classes of triterpenes, produced by the functionalization of their carbon skeleton. They can be categorized into different groups based on their structural formula/design. Triterpenoids are an important group of compounds that are widely used in the fields of pharmacology, food, and industrial biotechnology. However, inadequate synthetic methods and insufficient knowledge of the biosynthesis of triterpenoids, such as their structure, enzymatic activity, and the methods used to produce pure and active triterpenoids, are key problems that limit the production of these active metabolites. Here, we summarize the derivatives, pharmaceutical properties, and biosynthetic pathways of triterpenoids and review the enzymes involved in their biosynthetic pathway. Furthermore, we concluded the screening methods, identified the genes involved in the pathways, and highlighted the appropriate strategies used to enhance their biosynthetic production to facilitate the commercial process of triterpenoids through the synthetic biology method.

Item Details

Item Type:Refereed Article
Keywords:biosynthesis, triterpenoids, biosynthetic efficiency, enzyme, plant production, biochemistry, catalyst, screening, biotechnology, crops, pasture, genetic modification, agriculture, respiration, biodiversity, ecosystems services, environmental
Research Division:Agricultural, Veterinary and Food Sciences
Research Group:Agricultural biotechnology
Research Field:Agricultural biotechnology diagnostics (incl. biosensors)
Objective Division:Environmental Management
Objective Group:Terrestrial systems and management
Objective Field:Terrestrial biodiversity
UTAS Author:Liu, K (Mr Ke Liu)
UTAS Author:Harrison, MT (Associate Professor Matthew Harrison)
ID Code:149477
Year Published:2022
Deposited By:TIA - Research Institute
Deposited On:2022-04-01
Last Modified:2022-05-05

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