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Insulin resistance in the brain: Evidence supporting a role for inflammation, reactive microglia, and the impact of biological sex
Citation
Doust, YV and Sumargo, N and Ziebell, JM and Premilovac, D, Insulin resistance in the brain: Evidence supporting a role for inflammation, reactive microglia, and the impact of biological sex, Neuroendocrinology pp. 1-12. ISSN 0028-3835 (2022) [Refereed Article]
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Copyright Statement
Copyright 2022 S. Karger AG, Basel
Abstract
Increased intake of highly processed, energy-dense foods combined with a sedentary lifestyle are helping fuel the current overweight and obesity crisis, which is more prevalent in women than in men. Although peripheral organs such as adipose tissue contribute to the physiological development of obesity, emerging work aims to understand the role of the central nervous system to whole body energy homeostasis and development of weight gain and obesity. The present review discusses the impact of insulin, insulin resistance, free fatty acids, and inflammation on brain function and how these differ between the males and females in the context of obesity. We highlight the potential of microglia, the resident immune cells in the brain, as mediators of neuronal insulin resistance that drive reduced satiety, increased food intake and thus, obesity.
Item Details
Item Type: | Refereed Article |
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Keywords: | microglia, obesity, insulin resistance, inflammation |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Medical physiology |
Research Field: | Systems physiology |
Objective Division: | Expanding Knowledge |
Objective Group: | Expanding knowledge |
Objective Field: | Expanding knowledge in the biological sciences |
UTAS Author: | Doust, YV (Miss Yasmine Doust) |
UTAS Author: | Sumargo, N (Ms Nicole Sumargo) |
UTAS Author: | Ziebell, JM (Dr Jenna Ziebell) |
UTAS Author: | Premilovac, D (Dr Dino Premilovac) |
ID Code: | 149248 |
Year Published: | 2022 |
Deposited By: | Medicine |
Deposited On: | 2022-03-21 |
Last Modified: | 2022-11-17 |
Downloads: | 8 View Download Statistics |
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