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Safety of ceasing aspirin used without a clinical indication after age 70 years: a subgroup analysis of the ASPREE randomized trial
Citation
Nelson, MR and Polekhina, G and Reid, CM and Tonkin, AM and Murray, AM and Kirpach, B and Ernst, ME and Lockery, JE and Shah, RC and Stocks, N and Orchard, SG and Zhou, Z, Safety of ceasing aspirin used without a clinical indication after age 70 years: a subgroup analysis of the ASPREE randomized trial, Annals of Internal Medicine, 175, (5) pp. 1-4. ISSN 0003-4819 (2022) [Letter or Note in Journal]
Copyright Statement
Copyright 2022 American College of Physicians
DOI: doi:10.7326/M21-3823
Abstract
Background: The ASPREE (ASPirin in Reducing Events in
the Elderly) trial was a randomized, double-blind, placebocontrolled
primary prevention trial of aspirin in 19114 communitydwelling
persons aged 70 years and older (≥65 years in U.S.
racial minorities). The results of the trial demonstrated that aspirin
had no benefit for disability-free survival, prevention of cardiovascular
disease events, or prevention of incident cancer,
and increased risk for major bleeding and all-cause mortality
(1–3). These findings were interpreted by some as being relevant
only to aspirin initiation and not aspirin discontinuation (4).
The availability of evidence to inform the risks (for example, forgone
cardiovascular protection) and benefits (for example,
decreased risk for major hemorrhage) from aspirin cessation
among older adults is timely, given updated guideline recommendations
regarding aspirin use and clinical uncertainty (5).
Objective: To investigate the effect of aspirin cessation versus continuation on disability-free survival and other clinical outcomes in a post hoc analysis of ASPREE participants who were regularly taking aspirin before trial enrollment.
Item Details
Item Type: | Letter or Note in Journal |
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Keywords: | aspirin, cessation, safety, cardiovascular disease, bleeding, elderly |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Cardiovascular medicine and haematology |
Research Field: | Cardiology (incl. cardiovascular diseases) |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Efficacy of medications |
UTAS Author: | Nelson, MR (Professor Mark Nelson) |
UTAS Author: | Zhou, Z (Dr Zhen Zhou) |
ID Code: | 149210 |
Year Published: | 2022 |
Web of Science® Times Cited: | 2 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2022-03-17 |
Last Modified: | 2022-09-20 |
Downloads: | 0 |
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