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Pros and cons of pharmacological manipulation of cGMP-PDEs in the prevention and treatment of breast cancer
Citation
Di Iorio, P and Ronci, M and Giuliani, P and Caciagli, F and Ciccarelli, R and Caruso, V and Beggiato, S and Zuccarini, M, Pros and cons of pharmacological manipulation of cGMP-PDEs in the prevention and treatment of breast cancer, International Journal of Molecular Sciences, 23, (1) pp. 1-16. ISSN 1422-0067 (2022) [Substantial Review]
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Abstract
The cyclic nucleotides, cAMP and cGMP, are ubiquitous second messengers responsible for translating extracellular signals to intracellular biological responses in both normal and tumor cells. When these signals are aberrant or missing, cells may undergo neoplastic transformation or become resistant to chemotherapy. cGMP-hydrolyzing phosphodiesterases (PDEs) are attracting tremendous interest as drug targets for many diseases, including cancer, where they regulate cell growth, apoptosis and sensitization to radio- and chemotherapy. In breast cancer, PDE5 inhibition is associated with increased intracellular cGMP levels, which is responsible for the phosphorylation of PKG and other downstream molecules involved in cell proliferation or apoptosis. In this review, we provide an overview of the most relevant studies regarding the controversial role of PDE inhib-itors as off-label adjuvants in cancer therapy.
Item Details
| Item Type: | Substantial Review |
|---|---|
| Keywords: | purinergic system, drug discovery |
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Pharmacology and pharmaceutical sciences |
| Research Field: | Pharmaceutical sciences |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Treatment of human diseases and conditions |
| UTAS Author: | Caruso, V (Dr Vanni Caruso) |
| ID Code: | 148907 |
| Year Published: | 2022 |
| Web of Science® Times Cited: | 1 |
| Deposited By: | Pharmacy |
| Deposited On: | 2022-02-18 |
| Last Modified: | 2022-02-21 |
| Downloads: | 0 |
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