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Adipose stromal/stem cell-derived extracellular vesicles: potential next-generation anti-obesity agents


Zuccarini, M and Giuliani, P and Di Liberto, V and Frinchi, M and Caciagli, F and Caruso, V and Ciccarelli, R and Mudo, G and Di Iorio, P, Adipose stromal/stem cell-derived extracellular vesicles: potential next-generation anti-obesity agents, International Journal of Molecular Sciences, 23, (3) Article 1543. ISSN 1422-0067 (2022) [Refereed Article]

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Copyright Statement

2022. The Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) License ( The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

DOI: doi:10.3390/ijms23031543


Over the last decade, several compounds have been identified for the treatment of obesity. However, due to the complexity of the disease, many pharmacological interventions have raised concerns about their efficacy and safety. Therefore, it is important to discover new factors involved in the induction/progression of obesity. Adipose stromal/stem cells (ASCs), which are mostly isolated from subcutaneous adipose tissue, are the primary cells contributing to the expansion of fat mass. Like other cells, ASCs release nanoparticles known as extracellular vesicles (EVs), which are being actively studied for their potential applications in a variety of diseases. Here, we focused on the importance of the contribution of ASC-derived EVs in the regulation of metabolic processes. In addition, we outlined the advantages/disadvantages of the use of EVs as potential next-generation anti-obesity agents.

Item Details

Item Type:Refereed Article
Keywords:obesity, weight loss, metabolic disease/syndrome, extracellular vesicles, adipose tissue, adipose stromal/stem cells (ASCs)
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Pharmaceutical sciences
Objective Division:Health
Objective Group:Clinical health
Objective Field:Treatment of human diseases and conditions
UTAS Author:Caruso, V (Dr Vanni Caruso)
ID Code:148906
Year Published:2022
Deposited By:Pharmacy
Deposited On:2022-02-18
Last Modified:2022-03-04
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