Haik, J and Ullman, Y and Gur, E and Ad-El, D and Egozi, D and Kruchevsky, R and Zissman, S and Biros, E and Nir, R-R and Kornhaber, R and Cleary, M and Harats, M, Advances in the use of electrospun nanofibrous polymeric matrix for dermal healing at the donor site after the split-thickness skin graft excision: a prospective, randomized, controlled, open-label, multicenter study, Journal of Burn Care & Research pp. 1-10. ISSN 1559-047X (2021) [Refereed Article]
© The Author(s) 2021. Published by Oxford University Press on behalf of the American Burn Association. All rights reserved.
Dressings used to manage donor site wounds (DSWs) have up to 40% of patients experiencing complications that may cause suboptimal scarring. We evaluated the efficacy and safety of a portable electrospun nanofibrous matrix that provides contactless management of DSWs compared with standard dressing techniques. This study included adult patients who underwent an excised split-thickness skin graft (STSG) with a DSW area of 10 to 200 cm2. Patients were allocated into two groups; ie, the nanofiber group managed with a nanofibrous polymer-based matrix, and the control group managed using the standard of care such as Jelonet® or Biatain® Ibu dressing. Primary outcomes were postoperative dermal healing efficacy assessed by Draize scores. The time to complete re-epithelialization was also recorded. Secondary outcomes included postoperative adverse events, pain, and infections during the first 21 days and extended 12-month follow-up. The itching and scarring were recorded during the extended follow-up (months 1, 3, 6, 9, and 12) using Numerical-Analogue-Score and Vancouver scores, respectively. The nanofiber and control groups included 21 and 20 patients, respectively. The Draize dermal irritation scores were significantly lower in the nanofiber vs control group (Z = −2.509; P = .028) on the first postoperative day but became similar afterward (Z ≥ −1.62; P ≥ .198). In addition, the average time to re-epithelialization was similar in the nanofiber (17.9 ± 4.4 days) and control group (18.3 ± 4.5 days; Z = −0.299; P = .764), so were postoperative adverse events, pain, and infection incidence, itching and scarring. The safety and efficacy of electrospun nanofibrous matrix are similar to standard wound care allowing its use as an alternative donor site dressing following the STSG excision.
|Item Type:||Refereed Article|
|Keywords:||electrospun nanofibrous polymeric matrix, donor site, split-thickness skin graft, RCT|
|Research Group:||Biomedical engineering|
|Research Field:||Medical devices|
|Objective Field:||Medical instruments|
|UTAS Author:||Haik, J (Professor Josef Haik)|
|UTAS Author:||Kornhaber, R (Dr Rachel Kornhaber)|
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