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Temporal changes and risk factors for death from early withdrawal within 12 months of dialysis initiation—a cohort study
Citation
Chen, JHC and Brown, MA and Jose, M and Brennan, F and Johnson, DW and Roberts, MA and Wong, G and Cheikh Hassan, H and Kennard, A and Walker, R and Davies, CE and Boudville, N and Borlace, M and Hawley, C and Lim, WH, Temporal changes and risk factors for death from early withdrawal within 12 months of dialysis initiation a cohort study, Nephrology, Dialysis and Transplantation pp. 1-10. ISSN 0931-0509 (2021) [Refereed Article]
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Copyright Statement
Copyright 2021 The Author(s) Licensed under Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) https://creativecommons.org/licenses/by-nc/4.0/
Abstract
Background: Mortality risk is high soon after dialysis initiation in patients with kidney failure, and dialysis withdrawal is a major cause of early mortality, attributed to psychosocial or medical reasons. The temporal trends and risk factors associated with cause-specific early dialysis withdrawal within 12 months of dialysis initiation remain uncertain.
Methods: Using data from the Australia and New Zealand Dialysis and Transplant Registry, we examined the temporal trends and risk factors associated with mortality attributed to early psychosocial and medical withdrawals in incident adult dialysis patients in Australia between 2005 and 2018 using adjusted competing risk analyses.
Results: Of 32 274 incident dialysis patients, 3390 (11%) experienced death within 12 months post-dialysis initiation. Of these, 1225 (36%) were attributed to dialysis withdrawal, with 484 (14%) psychosocial withdrawals and 741 (22%) medical withdrawals. These patterns remained unchanged over the past two decades. Factors associated with increased risk of death from early psychosocial and medical withdrawals were older age, dialysis via central venous catheter, late referral and the presence of cerebrovascular disease; obesity and Asian ethnicity were associated with decreased risk. Risk factors associated with early psychosocial withdrawals were underweight and higher socioeconomic status. Presence of peripheral vascular disease, chronic lung disease and cancers were associated with early medical withdrawals.
Item Details
Item Type: | Refereed Article |
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Keywords: | dialysis, frailty, kidney supportive care, mortality, treatment withdrawal, chronic kidney disease, end-stage kidney disease, transplant |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Clinical sciences |
Research Field: | Nephrology and urology |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Treatment of human diseases and conditions |
UTAS Author: | Jose, M (Professor Matthew Jose) |
ID Code: | 148636 |
Year Published: | 2021 |
Web of Science® Times Cited: | 3 |
Deposited By: | Medicine |
Deposited On: | 2022-01-31 |
Last Modified: | 2022-04-22 |
Downloads: | 14 View Download Statistics |
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