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An omega 3 fatty acid supplemented diet was not associated with enhanced survival in maintenance haemodialysis: the Fish and Fruit Study

Citation

Barzi, F and Hughes, JT and Singh, G and Lawton, P and Coffey, P and Jose, M and Snelling, P and Hall, H and Cass, A and O'Dea, K, An omega 3 fatty acid supplemented diet was not associated with enhanced survival in maintenance haemodialysis: the Fish and Fruit Study, Renal Society of Australasia Journal, 16, (2) pp. 69-82. ISSN 2208-4088 (2020) [Refereed Article]

Copyright Statement

Copyright 2020 Renal Society of Australasia

DOI: doi:10.33235/rsaj.16.2.69-82

Abstract

Background: Aboriginal people requiring haemodialysis experience high cardiovascular mortality. Dietary interventions have uncertain effects on mortality and cardiovascular events in people with end-stage kidney disease (ESKD).

Aim: To determine if a dietary intervention of fish and fruit would decrease all-cause and cardiovascular mortality in Aboriginal people requiring haemodialysis.

Methods: A randomised dietary intervention of 300gm fish and five portions of fruit spaced over three dialysis treatments per week versus usual renal diet. Blood concentrations of omega-3 and omega-6 polyunsaturated fatty acids (n-3 PUFA and n-6 PUFA respectively) were recorded over a 12-month period.

Results: The mean age of the 151 randomised patients was 53 years; 42% were males, 94% of Aboriginal people and 74% with diabetes. There was no significant difference in n-3 PUFA concentration over the follow-up. The cardiovascular mortality rate was not different between the intervention and control group assessed at 2.1 years follow-up (3.7 v 4.3%, p=0.92), or at 5.0 years follow-up (19.7% v 21.8%, p=0.93).

Conclusions: The 12-month diet intervention including fish and fruit meal supplementation did not provide a survival advantage in patients with very low baseline n-3:n-6 PUFA ratio.

Item Details

Item Type:Refereed Article
Keywords:haemodialysis, diet, aboriginal, mortality, cardiovascular disease, chronic kidney disease, dialysis, end-stage kidney disease, cardiovascular
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Nephrology and urology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Treatment of human diseases and conditions
UTAS Author:Jose, M (Professor Matthew Jose)
ID Code:148634
Year Published:2020
Deposited By:Medicine
Deposited On:2022-01-31
Last Modified:2022-04-13
Downloads:0

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