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New horizons - cognitive dysfunction associated with type 2 diabetes

journal contribution
posted on 2023-05-23, 00:04 authored by Moran, C, Than, S, Michele CallisayaMichele Callisaya, Beare, R, Srikanth, V
The prevalence of type 2 diabetes (T2D) and cognitive dysfunction increases with age. As society ages, clinicians will be increasingly tasked with managing older people who have both T2D and cognitive dysfunction. T2D is associated with an increased risk of cognitive dysfunction and hence there is increasing interest in whether T2D is a causal factor in the pathogenesis of cognitive decline and dementia. Recent advances in the use of sensitive measures of in vivo brain dysfunction in life-course studies can help understand potential mechanistic pathways and also help guide recommendations for clinical practice.

In this article we will describe new horizons in the understanding of cognitive dysfunction associated with T2D. Coming from a clinical perspective, we discuss potential mechanisms and pathways linking the 2 conditions and the contribution of multimodal neuroimaging and study designs to advancing understanding in the field. We also highlight the important issues on the horizon that will need addressing in clinical identification, management, and risk reduction for people with coexistent T2D and cognitive dysfunction.

History

Publication title

Journal of Clinical Endocrinology and Metabolism

Pagination

1-14

ISSN

0021-972X

Department/School

Menzies Institute for Medical Research

Publisher

Endocrine Soc

Place of publication

4350 East West Highway Suite 500, Bethesda, USA, Md, 20814-4110

Repository Status

  • Restricted

Socio-economic Objectives

Health related to ageing

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