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The prevalence of type 2 diabetes (T2D) and cognitive dysfunction increases with age. As society ages, clinicians will be increasingly tasked with managing older people who have both T2D and cognitive dysfunction. T2D is associated with an increased risk of cognitive dysfunction and hence there is increasing interest in whether T2D is a causal factor in the pathogenesis of cognitive decline and dementia. Recent advances in the use of sensitive measures of in vivo brain dysfunction in life-course studies can help understand potential mechanistic pathways and also help guide recommendations for clinical practice.

In this article we will describe new horizons in the understanding of cognitive dysfunction associated with T2D. Coming from a clinical perspective, we discuss potential mechanisms and pathways linking the 2 conditions and the contribution of multimodal neuroimaging and study designs to advancing understanding in the field. We also highlight the important issues on the horizon that will need addressing in clinical identification, management, and risk reduction for people with coexistent T2D and cognitive dysfunction.

Item Type:	Substantial Review
Keywords:	diabetes, dementia, cognitive dysfunction
Research Division:	Biomedical and Clinical Sciences
Research Group:	Clinical sciences
Research Field:	Geriatrics and gerontology
Objective Division:	Health
Objective Group:	Specific population health (excl. Indigenous health)
Objective Field:	Health related to ageing
UTAS Author:	Callisaya, M (Dr Michele Callisaya)
ID Code:	148602
Year Published:	2021
Web of Science® Times Cited:	13
Deposited By:	Menzies Institute for Medical Research
Deposited On:	2022-01-27
Last Modified:	2022-01-31
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