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Translation of animal endocannabinoid models of PTSD mechanisms to humans: where to next?


Ney, LJ and Crombie, KM and Mayo, LM and Felmingham, KL and Bowser, T and Matthews, A, Translation of animal endocannabinoid models of PTSD mechanisms to humans: where to next?, Neuroscience and Biobehavioral Reviews, 132 pp. 76-91. ISSN 0149-7634 (2022) [Refereed Article]

Copyright Statement

2021 Elsevier Ltd. All rights reserved.

DOI: doi:10.1016/j.neubiorev.2021.11.040


The endocannabinoid system is known to be involved in mechanisms relevant to PTSD aetiology and maintenance, though this understanding is mostly based on animal models of the disorder. Here we review how human paradigms can successfully translate animal findings to human subjects, with the view that substantially increased insight into the effect of endocannabinoid signalling on stress responding, emotional and intrusive memories, and fear extinction can be gained using modern paradigms and methods for assessing the state of the endocannabinoid system in PTSD.

Item Details

Item Type:Refereed Article
Keywords:cannabinoids, endocannabinoids, posttraumatic stress disorder, stress, memory, fear conditioning, PTSD
Research Division:Psychology
Research Group:Biological psychology
Research Field:Biological psychology not elsewhere classified
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Mental health
UTAS Author:Ney, LJ (Mr Luke Ney)
UTAS Author:Matthews, A (Dr Allison Matthews)
ID Code:148464
Year Published:2022
Web of Science® Times Cited:4
Deposited By:Psychology
Deposited On:2022-01-13
Last Modified:2022-03-11

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