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Joint synovial macrophages as a potential target for intra-articular treatment of osteoarthritis-related pain


Wang, D and Chai, X-Q and Hu, S-S and Pan, F, Joint synovial macrophages as a potential target for intra-articular treatment of osteoarthritis-related pain, Osteoarthritis and Cartilage pp. 1-27. ISSN 1063-4584 (2021) [Refereed Article]

Copyright Statement

2021 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

DOI: doi:10.1016/j.joca.2021.11.014


Osteoarthritis is the most common form of joint disease and is one of the leading causes of chronic pain. Given the multi-factorial nature, numerous efforts have been made to clarify the multiple factors impacting the pain symptoms and joint pathology, including synovial macrophages in particular. Accumulating evidence from studies involving human participants and experimental animal models suggests that accumulating macrophages in synovial tissue are implicated in peripherally mediated pain sensitization of affected joints in osteoarthritis. Crosstalk between synovial macrophages and the innervating primary nociceptive neurons is thought to contribute to this facilitated pain processing by the peripheral nervous system. Due to high plasticity and complexity of synovial macrophages in the joint, safe therapies targeting single cells or molecules are currently lacking. Using advanced technologies (such as single-cell RNA sequencing and mass cytometry), studies have shown that diverse subpopulations of synovial macrophages exist in the distinct synovial microenvironments of specific osteoarthritis subtypes. Considerable progress has been made in delineating the molecular mechanisms of various subsets of synovial macrophages in the development of osteoarthritis. To develop a novel intra-articular treatment paradigm targeting synovial macrophages, we have summarized in this review the recent advances in identifying the functional consequences of synovial macrophage sub-populations and understanding of the molecular mechanisms driving macrophage-mediated remodeling.

Item Details

Item Type:Refereed Article
Keywords:joint pain, reprogramming, synovial macrophages
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Pain
Objective Division:Health
Objective Group:Clinical health
Objective Field:Human pain management
UTAS Author:Pan, F (Dr Feng Pan)
ID Code:148399
Year Published:2021
Web of Science® Times Cited:7
Deposited By:Menzies Institute for Medical Research
Deposited On:2022-01-05
Last Modified:2022-08-25

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