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Anti-inflammatory activity of fucoidan extracts in vitro
Citation
Ahmad, T and Eapen, MS and Ishaq, M and Park, AY and Karpiniec, SS and Stringer, DN and Sohal, SS and Fitton, JH and Guven, N and Caruso, V and Eri, R, Anti-inflammatory activity of fucoidan extracts in vitro, Marine Drugs, 19, (12) Article 702. ISSN 1660-3397 (2021) [Refereed Article]
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Copyright Statement
Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons 4.0 International (CC BY 4.0) license (https://creativecommons.org/licenses/by/4.0/).
Abstract
Fucoidans are sulfated, complex, fucose-rich polymers found in brown seaweeds. Fucoidans have been shown to have multiple bioactivities, including anti-inflammatory effects, and are
known to inhibit inflammatory processes via a number of pathways such as selectin blockade and
enzyme inhibition, and have demonstrated inhibition of inflammatory pathologies in vivo. In this
current investigation, fucoidan extracts from Undaria pinnatifida, Fucus vesiculosus, Macrocystis pyrifera,
Ascophyllum nodosum, and Laminaria japonica were assessed for modulation of pro-inflammatory
cytokine production (TNF-α, IL-1β, and IL-6) by human peripheral blood mononuclear cells (PBMCs)
and in a human macrophage line (THP-1). Fucoidan extracts exhibited no signs of cytotoxicity in
THP-1 cells after incubation of 48 h. Additionally, all fucoidan extracts reduced cytokine production in LPS stimulated PBMCs and human THP-1 cells in a dose-dependent fashion. Notably, the
5–30 kDa subfraction from Macrocystis pyrifera was a highly effective inhibitor at lower concentrations. Fucoidan extracts from all species had significant anti-inflammatory effects, but the lowest
molecular weight subfractions had maximal effects at low concentrations. These observations on
various fucoidan extracts offer insight into strategies that improve their efficacy against inflammationrelated pathology. Further studies should be conducted to elucidate the mechanism of action of
these extracts.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | Inflammation, fucoidan, fucoidan, PBMCs, THP-1, TNF-α, IL-1β, and IL-6, Undaria pinnatifida, Fucus vesiculosus, Macrocystis pyrifera, Ascophyllum nodosum, Laminaria japonica |
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Pharmacology and pharmaceutical sciences |
| Research Field: | Pharmaceutical sciences |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Treatment of human diseases and conditions |
| UTAS Author: | Ahmad, T (Mr Tauseef Ahmad) |
| UTAS Author: | Eapen, MS (Dr Mathew Eapen) |
| UTAS Author: | Ishaq, M (Dr Muhammad Ishaq) |
| UTAS Author: | Sohal, SS (Dr Sukhwinder Sohal) |
| UTAS Author: | Guven, N (Dr Nuri Guven) |
| UTAS Author: | Caruso, V (Dr Vanni Caruso) |
| UTAS Author: | Eri, R (Associate Professor Raj Eri) |
| ID Code: | 148334 |
| Year Published: | 2021 |
| Web of Science® Times Cited: | 17 |
| Deposited By: | Pharmacy |
| Deposited On: | 2021-12-22 |
| Last Modified: | 2022-08-17 |
| Downloads: | 17 View Download Statistics |
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