The first natural product isolation studies of Nothofagus gunnii (Hook.f.) Oerst and Nothofagus cunninghamii (Hook.f.) Oerst have been undertaken. A previously unreported stilbene derivative, pinosylvin monoacetate, was isolated from the leaves of N. gunnii, in addition to 14 known compounds; including the flavonoids galangin, pinobanksin, catechin and quercetin; sesquiterpenoids such as, ilicol and (+)-β-costol acetate; 2,4-dihydroxy-6-methoxychalcone and pinosylvin. Four known flavonoid natural products, catechin, quercetin, ayanin, and avicularin were isolated from the leaves of N. cunninghamii. This study reveals that N. gunnii is a rich source of flavonoid, chalcone and stilbene compounds, while primarily hydroxyflavonoid compounds are found in N. cunninghamii. The isolated phytochemicals are consistent with the evolutionary relationships suggested to exist among Nothofagus species.

Item Type:	Refereed Article
Keywords:	Nothofagus gunnii, Nothofagus cunninghamii, flavonoids, terpenoids, stilbenes
Research Division:	Chemical Sciences
Research Group:	Organic chemistry
Research Field:	Natural products and bioactive compounds
Objective Division:	Expanding Knowledge
Objective Group:	Expanding knowledge
Objective Field:	Expanding knowledge in the chemical sciences
UTAS Author:	Gyeltshen, T (Mr Thinley Gyeltshen)
UTAS Author:	Jordan, GJ (Professor Greg Jordan)
UTAS Author:	Smith, JA (Associate Professor Jason Smith)
UTAS Author:	Bissember, AC (Associate Professor Alex Bissember)
ID Code:	147919
Year Published:	2022
Funding Support:	Australian Research Council (FT200100049)
Deposited By:	Chemistry
Deposited On:	2021-11-24
Last Modified:	2022-04-07
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