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Effects of a physical activity intervention on brain atrophy in older adults at risk of dementia: a randomized controlled trial
journal contribution
posted on 2023-05-21, 04:10 authored by B Sinclair, Steward, C, Venkatraman, V, Aljondi, R, Cox, KL, Ellis, KA, Ames, D, Masters, CL, Phal, PM, Matthew SharmanMatthew Sharman, Cyarto, EV, Lai, MMY, Szoeke, C, Lautenschlager, NT, Desmond, PMLack of physical activity is a risk factor for dementia, however, the utility of interventional physical activity programs as a protective measure against brain atrophy and cognitive decline is uncertain. Here we present the effect of a randomized controlled trial of a 24-month physical activity intervention on global and regional brain atrophy as characterized by longitudinal voxel-based morphometry with T1-weighted MRI images. The study sample consisted of 98 participants at risk of dementia, with mild cognitive impairment or subjective memory complaints, and having at least one vascular risk factor for dementia, randomized into an exercise group and a control group. Between 0 and 24 months, there was no significant difference detected between groups in the rate of change in global, or regional brain volumes.
Funding
National Health & Medical Research Council
History
Publication title
Brain Imaging and BehaviorISSN
1931-7557Department/School
School of Health SciencesPublisher
SpringerPlace of publication
United StatesRights statement
© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021Repository Status
- Restricted