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Effects of a physical activity intervention on brain atrophy in older adults at risk of dementia: a randomized controlled trial

Citation

Sinclair, B and Steward, C and Venkatraman, V and Aljondi, R and Cox, KL and Ellis, KA and Ames, D and Masters, CL and Phal, PM and Sharman, MJ and Cyarto, EV and Lai, MMY and Szoeke, C and Lautenschlager, NT and Desmond, PM, Effects of a physical activity intervention on brain atrophy in older adults at risk of dementia: a randomized controlled trial, Brain Imaging and Behavior ISSN 1931-7557 (2021) [Refereed Article]


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DOI: doi:10.1007/s11682-021-00577-7

Abstract

Lack of physical activity is a risk factor for dementia, however, the utility of interventional physical activity programs as a protective measure against brain atrophy and cognitive decline is uncertain. Here we present the effect of a randomized controlled trial of a 24-month physical activity intervention on global and regional brain atrophy as characterized by longitudinal voxel-based morphometry with T1-weighted MRI images. The study sample consisted of 98 participants at risk of dementia, with mild cognitive impairment or subjective memory complaints, and having at least one vascular risk factor for dementia, randomized into an exercise group and a control group. Between 0 and 24 months, there was no significant difference detected between groups in the rate of change in global, or regional brain volumes.

Item Details

Item Type:Refereed Article
Keywords:dementia, mild cognitive impairment, physical activity, brain volume, voxel-based morphometry
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Neurology and neuromuscular diseases
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Mental health
UTAS Author:Sharman, MJ (Dr Matt Sharman)
ID Code:147785
Year Published:2021
Funding Support:National Health and Medical Research Council (APP1005942)
Deposited By:Health Sciences
Deposited On:2021-11-15
Last Modified:2021-11-15
Downloads:0

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