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Clinical features and mechanistic insights into drug repurposing for combating COVID-19

Citation

Asrani, P and Tiwari, K and Eapen, MS and McAlinden, KD and Haug, G and Johansen, MD and Hansbro, PM and Flanagan, KL and Hassan, MI and Sohal, SS, Clinical features and mechanistic insights into drug repurposing for combating COVID-19, International Journal of Biochemistry and Cell Biology ISSN 1357-2725 (2021) [Refereed Article]


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DOI: doi:10.1016/j.biocel.2021.106114

Abstract

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emerged from Wuhan in China before it spread to the entire globe. It causes coronavirus disease of 2019 (COVID-19) where mostly individuals present mild symptoms, some remain asymptomatic and some show severe lung inflammation and pneumonia in the host through the induction of a marked inflammatory 'cytokine storm'. New and efficacious vaccines have been developed and put into clinical practice in record time, however, there is a still a need for effective treatments for those who are not vaccinated or remain susceptible to emerging SARS-CoV-2 variant strains. Despite this, effective therapeutic interventions against COVID-19 remain elusive. Here we review potential drugs for COVID-19 classified on the basis of their mode of action. The mechanisms of action of each are discussed in detail to highlight the therapeutic targets that may help in reducing the global pandemic. The review was done up to July 2021 and the data was assessed through the official websites of WHO and CDC for collecting the information on the clinical trials. Moreover, the recent research papers were also assessed for the relevant data. The search was made based on keywords like Coronavirus, SARS-C0V-2, drugs (specific name of the drugs), COVID-19, clinical efficiency, safety profile, side-effects etc. This review outlines potential areas for future research into COVID-19 treatment strategies.

Item Details

Item Type:Refereed Article
Keywords:drugs, COPD, lung, asthma, COVID-19, respiratory, SARS-CoV-2, fibrosis
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Cardiology (incl. cardiovascular diseases)
Objective Division:Health
Objective Group:Clinical health
Objective Field:Diagnosis of human diseases and conditions
UTAS Author:Eapen, MS (Mr Mathew Eapen)
UTAS Author:McAlinden, KD (Mr Kielan McAlinden)
UTAS Author:Haug, G (Dr Greg Haug)
UTAS Author:Flanagan, KL (Dr Katie Flanagan)
UTAS Author:Sohal, SS (Dr Sukhwinder Sohal)
ID Code:147617
Year Published:2021
Deposited By:Health Sciences
Deposited On:2021-11-10
Last Modified:2021-11-11
Downloads:0

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