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Nanotechnology applications of flavonoids for viral diseases
Citation
Jannat, K and Paul, AK and Bondhon, TA and Hasan, A and Nawaz, M and Jahan, R and Mahboob, T and Nissapatorn, V and Wilairatana, P and de Lourdes Pereira, M and Rahmatullah, M, Nanotechnology applications of flavonoids for viral diseases, Pharmaceutics, 13, (11) pp. 1-40. ISSN 1999-4923 (2021) [Substantial Review]
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DOI: doi:10.3390/pharmaceutics13111895
Abstract
Recent years have witnessed the emergence of several viral diseases, including various
zoonotic diseases such as the current pandemic caused by the Severe Acute Respiratory Syndrome
Coronavirus 2 (SARS-CoV-2). Other viruses, which possess pandemic-causing potential include
avian flu, Ebola, dengue, Zika, and Nipah virus, as well as the re-emergence of SARS (Severe Acute
Respiratory Syndrome) and MERS (Middle East Respiratory Syndrome) coronaviruses. Notably, effective drugs or vaccines against these viruses are still to be discovered. All the newly approved
vaccines against the SARS-CoV-2-induced disease COVID-19 possess real-time possibility of becoming obsolete because of the development of ‘variants of concern’. Flavonoids are being increasingly
recognized as prophylactic and therapeutic agents against emerging and old viral diseases.Around
10,000 natural flavonoid compounds have been identified, being phytochemicals, all plant-based.
Flavonoids have been reported to have lesser side effects than conventional anti-viral agents and
are effective against more viral diseases than currently used anti-virals. Despite their abundance in
plants, which are a part of human diet, flavonoids have the problem of low bioavailability. Various
attempts are in progress to increase the bioavailability of flavonoids, one of the promising fields
being nanotechnology. This review is a narrative of some anti-viral dietary flavonoids, their bioavailability, and various means with an emphasis on the nanotechnology system(s) being experimented with to deliver anti-viral flavonoids, whose systems show potential in the efficient delivery
of flavonoids, resulting in increased bioavailability.
Item Details
| Item Type: | Substantial Review |
|---|---|
| Keywords: | flavonoids, anti-viral, nanotechnology, bioavailability, drug delivery |
| Research Division: | Engineering |
| Research Group: | Nanotechnology |
| Research Field: | Micro- and nanosystems |
| Objective Division: | Health |
| Objective Group: | Public health (excl. specific population health) |
| Objective Field: | Disease distribution and transmission (incl. surveillance and response) |
| UTAS Author: | Paul, AK (Dr Alok Paul) |
| ID Code: | 147587 |
| Year Published: | 2021 |
| Web of Science® Times Cited: | 4 |
| Deposited By: | Pharmacy |
| Deposited On: | 2021-11-09 |
| Last Modified: | 2021-11-10 |
| Downloads: | 0 |
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