eCite Digital Repository

Nanotechnology applications of flavonoids for viral diseases


Jannat, K and Paul, AK and Bondhon, TA and Hasan, A and Nawaz, M and Jahan, R and Mahboob, T and Nissapatorn, V and Wilairatana, P and de Lourdes Pereira, M and Rahmatullah, M, Nanotechnology applications of flavonoids for viral diseases, Pharmaceutics, 13, (11) pp. 1-40. ISSN 1999-4923 (2021) [Substantial Review]

Pending copyright assessment - Request a copy

DOI: doi:10.3390/pharmaceutics13111895


Recent years have witnessed the emergence of several viral diseases, including various zoonotic diseases such as the current pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Other viruses, which possess pandemic-causing potential include avian flu, Ebola, dengue, Zika, and Nipah virus, as well as the re-emergence of SARS (Severe Acute Respiratory Syndrome) and MERS (Middle East Respiratory Syndrome) coronaviruses. Notably, effective drugs or vaccines against these viruses are still to be discovered. All the newly approved vaccines against the SARS-CoV-2-induced disease COVID-19 possess real-time possibility of becoming obsolete because of the development of ‘variants of concern’. Flavonoids are being increasingly recognized as prophylactic and therapeutic agents against emerging and old viral diseases.Around 10,000 natural flavonoid compounds have been identified, being phytochemicals, all plant-based. Flavonoids have been reported to have lesser side effects than conventional anti-viral agents and are effective against more viral diseases than currently used anti-virals. Despite their abundance in plants, which are a part of human diet, flavonoids have the problem of low bioavailability. Various attempts are in progress to increase the bioavailability of flavonoids, one of the promising fields being nanotechnology. This review is a narrative of some anti-viral dietary flavonoids, their bioavailability, and various means with an emphasis on the nanotechnology system(s) being experimented with to deliver anti-viral flavonoids, whose systems show potential in the efficient delivery of flavonoids, resulting in increased bioavailability.

Item Details

Item Type:Substantial Review
Keywords:flavonoids, anti-viral, nanotechnology, bioavailability, drug delivery
Research Division:Engineering
Research Group:Nanotechnology
Research Field:Micro- and nanosystems
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Disease distribution and transmission (incl. surveillance and response)
UTAS Author:Paul, AK (Dr Alok Paul)
ID Code:147587
Year Published:2021
Web of Science® Times Cited:4
Deposited By:Pharmacy
Deposited On:2021-11-09
Last Modified:2021-11-10

Repository Staff Only: item control page