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Current status of endoplasmic reticulum stress in type ii diabetes

Citation

Mustapha, S and Mohammed, M and Azemi, AK and Jatau, AI and Shehu, A and Mustapha, L and Aliyu, IM and Danraka, RN and Amin, A and Bala, AA and Wan Ahmad, WAN and Rasool, AHG and Mustafa, MR and Mokhtar, SS, Current status of endoplasmic reticulum stress in type ii diabetes, Molecules, 26, (14) pp. 1-16. ISSN 1420-3049 (2021) [Refereed Article]


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DOI: doi:10.3390/molecules26144362

Abstract

The endoplasmic reticulum (ER) plays a multifunctional role in lipid biosynthesis, calcium storage, protein folding, and processing. Thus, maintaining ER homeostasis is essential for cellular functions. Several pathophysiological conditions and pharmacological agents are known to disrupt ER homeostasis, thereby, causing ER stress. The cells react to ER stress by initiating an adaptive signaling process called the unfolded protein response (UPR). However, the ER initiates death signaling pathways when ER stress persists. ER stress is linked to several diseases, such as cancer, obesity, and diabetes. Thus, its regulation can provide possible therapeutic targets for these. Current evidence suggests that chronic hyperglycemia and hyperlipidemia linked to type II diabetes disrupt ER homeostasis, thereby, resulting in irreversible UPR activation and cell death. Despite progress in understanding the pathophysiology of the UPR and ER stress, to date, the mechanisms of ER stress in relation to type II diabetes remain unclear. This review provides up-to-date information regarding the UPR, ER stress mechanisms, insulin dysfunction, oxidative stress, and the therapeutic potential of targeting specific ER stress pathways.

Item Details

Item Type:Refereed Article
Keywords:endoplasmic reticulum, endoplasmic reticulum stress, apoptosis, homeostasis, unfolded protein response, type II diabetes
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Clinical pharmacology and therapeutics
Objective Division:Health
Objective Group:Evaluation of health and support services
Objective Field:Determinants of health
UTAS Author:Jatau, AI (Mr Ibrahim Jatau Abubakar)
ID Code:147456
Year Published:2021
Deposited By:Menzies Institute for Medical Research
Deposited On:2021-11-02
Last Modified:2021-11-02
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