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Increasing incidence of invasive group A streptococcal disease in Western Australia, particularly among Indigenous people

Citation

Wright, CM and Moorin, R and Pearson, G and Dyer, JR and Carapetis, JR and Manning, L, Increasing incidence of invasive group A streptococcal disease in Western Australia, particularly among Indigenous people, Medical Journal of Australia, 215, (1) pp. 36-41. ISSN 0025-729X (2021) [Refereed Article]

Copyright Statement

2021 AMPCo Pty Ltd

DOI: doi:10.5694/mja2.51117

Abstract

Objective: To quantify the burden of invasive group A Streptococcus (GAS) disease in Western Australia during 2000-2018.

Design, setting: Population-based data linkage study: Hospital Morbidity Data Collection (HMDC; all WA public and private hospital records), PathWest pathology data (government-owned pathology services provider), and death registrations.

Participants: People with invasive GAS disease, defined by an isolate from a normally sterile site (PathWest) or a hospital-based principal ICD-10-AM diagnosis code (HMDC).

Main outcome measures: Incidence of invasive GAS disease; median length of hospital stay; all-cause mortality.

Results: We identified 2237 cases of GAS disease during 2000-2018; 1283 were in male patients (57%). 1950 cases had been confirmed by GAS isolates from normally sterile tissues (87%; including 1089 from blood [56% of cases] and 750 from tissue [38%]). The age-standardised incidence increased from 2.0 (95% CI, 1.4-2.7) cases per 100 000 population in 2000 to 9.1 (95% CI, 7.9-10.2) cases per 100 000 in 2017 (by year, adjusted for age group and sex: incidence rate ratio [IRR], 1.09; 95% CI, 1.08-1.10). Incidence was consistently higher among Indigenous than non-Indigenous Australians (year-adjusted IRR, 13.1; 95% CI, 11.3-15.1). All-cause 30-day mortality was 5% (116 deaths), and 90-day mortality 7% (156 deaths); 30-day mortality, adjusted for age group and sex, was not statistically significantly different for cases involving Indigenous or non-Indigenous patients (adjusted odds ratio, 0.8; 95% CI, 0.6-1.1).

Conclusions: The incidence of invasive GAS disease in WA increased between 2000 and 2018, particularly among Indigenous Australians. Mandatory notification of invasive GAS disease would therefore be appropriate. The social determinants of differences in incidence should be addressed, and other relevant host, pathogen, and health system factors investigated.

Item Details

Item Type:Refereed Article
Keywords:bacterial infections, communicable diseases, epidemiology, Indigenous health, public health, streptococcus
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Infectious diseases
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Disease distribution and transmission (incl. surveillance and response)
UTAS Author:Wright, CM (Mr Cameron Wright)
ID Code:147395
Year Published:2021
Web of Science® Times Cited:1
Deposited By:Pharmacy
Deposited On:2021-10-29
Last Modified:2021-11-22
Downloads:0

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