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Association between number of siblings and cardiovascular risk factors in childhood and in adulthood: The Cardiovascular Risk in Young Finns Study

Citation

Pihlman, J and Magnussen, CG and Rovio, SP and Pahkala, K and Jokinen, E and Laitinen, TP and Hutri-Kahonen, N and Tossavainen, P and Taittonen, L and Kahonen, M and Viikari, JSA and Raitakari, OT and Juonala, M and Nuotio, J, Association between number of siblings and cardiovascular risk factors in childhood and in adulthood: The Cardiovascular Risk in Young Finns Study, Journal of Pediatrics, 237 pp. 87-95.e1. ISSN 0022-3476 (2021) [Refereed Article]


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Copyright Statement

Copyright 2021 The Authors. Published by Elsevier Inc. This is an open access article under the Creative Commons Attribution 4.0 International (CC BY 4.0) license (http://creativecommons.org/licensesby4.0/).

DOI: doi:10.1016/j.jpeds.2021.05.058

Abstract

Objective:To determine the association of number of siblings on cardiovascular risk factors in childhood and in adulthood.

Study design: In total, 3554 participants (51% female) from the Cardiovascular Risk in Young Finns Study with cardiovascular disease risk factor data at baseline 1980 (age 3-18 years) and 2491 participants with longitudinal risk factor data at the 2011 follow-up. Participants were categorized by number of siblings at baseline (0, 1, or more than 1). Risk factors (body mass index, physical activity, hypertension, dyslipidemia, and overweight, and metabolic syndrome) in childhood and in adulthood were used as outcomes. Analyses were adjusted for age and sex.

Results: In childhood, participants without siblings had higher body mass index (18.2 kg/m2, 95% CI 18.0-18.3) than those with 1 sibling (17.9 kg/m2, 95% CI 17.8-18.0) or more than 1 sibling (17.8 kg/m2, 95% CI 17.7-17.9). Childhood physical activity index was lower among participants without siblings (SD -0.08, 95% CI -0.16-0.00) compared with participants with 1 sibling (SD 0.06, 95%CI 0.01-0.11) or more than 1 sibling (SD -0.02, 95% CI -0.07-0.03). OR for adulthood hypertension was lower among participants with 1 sibling (OR 0.73, 95% CI 0.54-0.98) and more than 1 sibling (OR 0.71, 95% CI 0.52-0.97) compared with participants with no siblings. OR for obesity was lower among participants with 1 sibling (OR 0.72, 95% CI 0.54-0.95) and more than 1 sibling (OR 0.75, 95% CI 0.56-1.01) compared with those with no siblings.

Conclusions: Children without siblings had poorer cardiovascular risk factor levels in childhood and in adulthood. The number of siblings could help identify individuals at increased risk that might benefit from early intervention.

Item Details

Item Type:Refereed Article
Keywords:birth order, cardiovascular disease, family size, risk factor
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Cardiology (incl. cardiovascular diseases)
Objective Division:Health
Objective Group:Evaluation of health and support services
Objective Field:Determinants of health
UTAS Author:Magnussen, CG (Associate Professor Costan Magnussen)
ID Code:147341
Year Published:2021
Deposited By:Menzies Institute for Medical Research
Deposited On:2021-10-27
Last Modified:2021-11-18
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