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Generation of MNZTASi001-A, a human pluripotent stem cell line from a person with primary progressive multiple sclerosis

Citation

Mehta, A and Lu, P and Taylor, BV and Charlesworth, J and Cook, AL and Burdon, KP and Hewitt, AW and Young, KM, Generation of MNZTASi001-A, a human pluripotent stem cell line from a person with primary progressive multiple sclerosis, Stem Cell Research pp. 1-4. ISSN 1873-5061 (2021) [Refereed Article]


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DOI: doi:10.1016/j.scr.2021.102568

Abstract

Multiple sclerosis (MS) is a chronic autoimmune and neurodegenerative disease that results in immune cell infiltration of the central nervous system (CNS) and demyelination in young adults. Substantial progress has been made in developing disease modifying therapies for people with relapsing-remitting MS, but options remain limited for people with primary progressive MS (PPMS). PPMS accounts for ~15% of MS diagnoses. Herein, we generated a human induced pluripotent stem cell line (hiPSC) from a person with clinically definite PPMS. This disease-specific hiPSC line will be useful for studying PPMS in vitro, allowing the generation of immune and CNS cell types.

Item Details

Item Type:Refereed Article
Keywords:induced pluripotent stem cell (iPSC), multiple sclerosis, progressive multiple sclerosis
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Cellular nervous system
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the biomedical and clinical sciences
UTAS Author:Mehta, A (Dr Ashish Mehta)
UTAS Author:Taylor, BV (Professor Bruce Taylor)
UTAS Author:Charlesworth, J (Dr Jac Charlesworth)
UTAS Author:Cook, AL (Associate Professor Tony Cook)
UTAS Author:Burdon, KP (Professor Kathryn Burdon)
UTAS Author:Hewitt, AW (Professor Alex Hewitt)
UTAS Author:Young, KM (Associate Professor Kaylene Young)
ID Code:147321
Year Published:2021
Deposited By:Menzies Institute for Medical Research
Deposited On:2021-10-26
Last Modified:2021-11-01
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