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Generation of MNZTASi001-A, a human pluripotent stem cell line from a person with primary progressive multiple sclerosis
Citation
Mehta, A and Lu, P and Taylor, BVM and Charlesworth, J and Cook, AL and Burdon, KP and Hewitt, AW and Young, KM, Generation of MNZTASi001-A, a human pluripotent stem cell line from a person with primary progressive multiple sclerosis, Stem Cell Research, 57 pp. 1-4. ISSN 1873-5061 (2021) [Refereed Article]
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Copyright Statement
© 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
DOI: doi:10.1016/j.scr.2021.102568
Abstract
Multiple sclerosis (MS) is a chronic autoimmune and neurodegenerative disease that results in immune cell
infiltration of the central nervous system (CNS) and demyelination in young adults. Substantial progress has been
made in developing disease modifying therapies for people with relapsing-remitting MS, but options remain
limited for people with primary progressive MS (PPMS). PPMS accounts for ~15% of MS diagnoses. Herein, we
generated a human induced pluripotent stem cell line (hiPSC) from a person with clinically definite PPMS. This
disease-specific hiPSC line will be useful for studying PPMS in vitro, allowing the generation of immune and CNS
cell types.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | induced pluripotent stem cell (iPSC), multiple sclerosis, progressive multiple sclerosis |
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Neurosciences |
| Research Field: | Cellular nervous system |
| Objective Division: | Expanding Knowledge |
| Objective Group: | Expanding knowledge |
| Objective Field: | Expanding knowledge in the biomedical and clinical sciences |
| UTAS Author: | Mehta, A (Dr Ashish Mehta) |
| UTAS Author: | Taylor, BVM (Professor Bruce Taylor) |
| UTAS Author: | Charlesworth, J (Dr Jac Charlesworth) |
| UTAS Author: | Cook, AL (Associate Professor Tony Cook) |
| UTAS Author: | Burdon, KP (Professor Kathryn Burdon) |
| UTAS Author: | Hewitt, AW (Professor Alex Hewitt) |
| UTAS Author: | Young, KM (Associate Professor Kaylene Young) |
| ID Code: | 147321 |
| Year Published: | 2021 |
| Web of Science® Times Cited: | 1 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2021-10-26 |
| Last Modified: | 2021-12-09 |
| Downloads: | 7 View Download Statistics |
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