147321 - generation of MNZTASi001 A.pdf (5.41 MB)
Generation of MNZTASi001-A, a human pluripotent stem cell line from a person with primary progressive multiple sclerosis
journal contribution
posted on 2023-05-21, 03:29 authored by Ashish Mehta, Lu, P, Bruce TaylorBruce Taylor, Jac CharlesworthJac Charlesworth, Anthony CookAnthony Cook, Kathryn BurdonKathryn Burdon, Alexander HewittAlexander Hewitt, Kaylene YoungKaylene YoungMultiple sclerosis (MS) is a chronic autoimmune and neurodegenerative disease that results in immune cell infiltration of the central nervous system (CNS) and demyelination in young adults. Substantial progress has been made in developing disease modifying therapies for people with relapsing-remitting MS, but options remain limited for people with primary progressive MS (PPMS). PPMS accounts for ~15% of MS diagnoses. Herein, we generated a human induced pluripotent stem cell line (hiPSC) from a person with clinically definite PPMS. This disease-specific hiPSC line will be useful for studying PPMS in vitro, allowing the generation of immune and CNS cell types.
Funding
Medical Research Future Fund
History
Publication title
Stem Cell ResearchVolume
57Pagination
1-4ISSN
1873-5061Department/School
Menzies Institute for Medical ResearchPublisher
ElsevierPlace of publication
United KingdomRights statement
© 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license (http://creativecommons.org/licenses/by-nc-nd/4.0/)Repository Status
- Open