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Corticosterone administration alters white matter tract structure and reduces gliosis in the sub-acute phase of experimental stroke
Citation
Zalewska, K and Hood, RJ and Pietrogrande, G and Sanchez-Bezanilla, S and Ong, LK and Johnson, SJ and Young, KM and Nilsson, M and Walker, FR, Corticosterone administration alters white matter tract structure and reduces gliosis in the sub-acute phase of experimental stroke, International Journal of Molecular Sciences, 22, (13) Article 6693. ISSN 1661-6596 (2021) [Refereed Article]
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Copyright Statement
Copyright 2021 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
Abstract
White matter tract (WMT) degeneration has been reported to occur following a stroke, and it is associated with post-stroke functional disturbances. White matter pathology has been suggested to be an independent predictor of post-stroke recovery. However, the factors that influence WMT remodeling are poorly understood. Cortisol is a steroid hormone released in response to prolonged stress, and elevated levels of cortisol have been reported to interfere with brain recovery. The objective of this study was to investigate the influence of corticosterone (CORT; the rodent equivalent of cortisol) on WMT structure post-stroke. Photothrombotic stroke (or sham surgery) was induced in 8-week-old male C57BL/6 mice. At 72 h, mice were exposed to standard drinking water ± CORT (100 µg/mL). After two weeks of CORT administration, mice were euthanised and brain tissue collected for histological and biochemical analysis of WMT (particularly the corpus callosum and corticospinal tract). CORT administration was associated with increased tissue loss within the ipsilateral hemisphere, and modest and inconsistent WMT reorganization. Further, a structural and molecular analysis of the WMT components suggested that CORT exerted effects over axons and glial cells. Our findings highlight that CORT at stress-like levels can moderately influence the reorganization and microstructure of WMT post-stroke.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | white matter tracts, stroke recovery, oligodendrocyte, myelin, stress, corticosterone, glia |
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Neurosciences |
| Research Field: | Neurology and neuromuscular diseases |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Treatment of human diseases and conditions |
| UTAS Author: | Young, KM (Professor Kaylene Young) |
| ID Code: | 147278 |
| Year Published: | 2021 |
| Web of Science® Times Cited: | 3 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2021-10-22 |
| Last Modified: | 2022-12-06 |
| Downloads: | 10 View Download Statistics |
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