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Mapping cerebellar abiotrophy in Australian Kelpies
Citation
Shearman, JR and Cook, RW and McCowan, C and Fletcher, JL and Taylor, RM and Wilton, AN, Mapping cerebellar abiotrophy in Australian Kelpies, Animal Genetics, 42, (6) pp. 675-678. ISSN 0268-9146 (2011) [Refereed Article]
Copyright Statement
copyright 2011 The Authors, Animal Genetics 2011 Stichting International Foundation for Animal Genetics
DOI: doi:10.1111/j.1365-2052.2011.02199.x
Abstract
An autosomal recessive form of cerebellar abiotrophy occurs in Australian Kelpie dogs. Clinical signs range from mild ataxia with intention tremor to severe ataxia with seizures. A whole-genome mapping analysis was performed using Affymetrix Canine SNP array v2 on 11 affected and 19 control dogs, but there was no significant association with disease. A homozygosity analysis identified a three megabase region likely to contain the disease mutation. The region spans 29.8-33 Mb on chromosome 3, for which all affected dogs were homozygous for a common haplotype. Microsatellite markers were developed in the candidate region for linkage analysis that resulted in a logarithm of odds score suggestive of linkage. The candidate region contains 29 genes, none of which are known to cause ataxia.
Item Details
Item Type: | Refereed Article |
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Keywords: | gene mapping, cerebellar abiotrophy, domesticated species |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Neurosciences |
Research Field: | Neurology and neuromuscular diseases |
Objective Division: | Animal Production and Animal Primary Products |
Objective Group: | Livestock raising |
Objective Field: | Livestock raising not elsewhere classified |
UTAS Author: | Fletcher, JL (Dr Jessica Fletcher) |
ID Code: | 147209 |
Year Published: | 2011 |
Web of Science® Times Cited: | 6 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2021-10-19 |
Last Modified: | 2021-12-08 |
Downloads: | 0 |
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