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Myelin Protein Zero180–199 Peptide Induced Experimental Autoimmune Neuritis in C57BL/6 Mice


Gonsalvez, DG and Yoo, SW and Craig, GA and Wood, RJ and Fletcher, JL and Murray, SS and Xiao, J, Myelin Protein Zero180-199 Peptide Induced Experimental Autoimmune Neuritis in C57BL/6 Mice, Myelin, Humana Press, A Woodhoo (ed), United States, pp. 243-250. ISBN 978-1-4939-7861-8 (2018) [Research Book Chapter]

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Copyright 2018 Springer Science+Business Media, LLC, part of Springer Nature 2018


Mouse models of peripheral demyelinating neuropathy play an important role in enabling the study of disease pathogenesis. Further, induction in transgenic mice allows for the precise interrogation of disease mechanisms, as well as the analysis of the efficacy and mechanisms of potential new therapies. Here we describe a method to successfully induce experimental autoimmune neuritis (EAN) using myelin protein zero (P0)180–199 peptide in combination with Freund’s complete adjuvant and pertussis toxin in the C57BL/6 mouse strain. We also outline a sensitive paradigm of accurately assessing the extent of functional deficits occurring in murine EAN.

Item Details

Item Type:Research Book Chapter
Keywords:peripheral nervous system, demyelinating disease, animal model, Experimental autoimmune neuritis, myelin, P0, peripheral neuropathy, C57BL/6 mice
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Cellular nervous system
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the biomedical and clinical sciences
UTAS Author:Fletcher, JL (Dr Jessica Fletcher)
ID Code:147205
Year Published:2018
Deposited By:Menzies Institute for Medical Research
Deposited On:2021-10-19
Last Modified:2021-11-05

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