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Brain-derived neurotrophic factor in central nervous system myelination: A new mechanism to promote myelin plasticity and repair

Citation

Fletcher, JL and Murray, SS and Xiao, J, Brain-derived neurotrophic factor in central nervous system myelination: A new mechanism to promote myelin plasticity and repair, International Journal of Molecular Sciences, 19, (12) pp. 1-16. ISSN 1422-0067 (2018) [Refereed Article]


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Copyright Statement

Copyright: 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons 4.0 International (CC BY 4.0) license (https://creativecommons.org/licenses/by/4.0/).

DOI: doi:10.3390/ijms19124131

Abstract

Brain-derived neurotrophic factor (BDNF) plays vitally important roles in neural development and plasticity in both health and disease. Recent studies using mutant mice to selectively manipulate BDNF signalling in desired cell types, in combination with animal models of demyelinating disease, have demonstrated that BDNF not only potentiates normal central nervous system myelination in development but enhances recovery after myelin injury. However, the precise mechanisms by which BDNF enhances myelination in development and repair are unclear. Here, we review some of the recent progress made in understanding the influence BDNF exerts upon the myelinating process during development and after injury, and discuss the cellular and molecular mechanisms underlying its effects. In doing so, we raise new questions for future research.

Item Details

Item Type:Refereed Article
Keywords:oligodendrocyte, myelin, BDNF, multiple sclerosis, TrkB
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Cellular nervous system
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the biomedical and clinical sciences
UTAS Author:Fletcher, JL (Dr Jessica Fletcher)
ID Code:147204
Year Published:2018
Web of Science® Times Cited:38
Deposited By:Menzies Institute for Medical Research
Deposited On:2021-10-19
Last Modified:2021-11-18
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