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Efficacy of epothilones in central nervous system trauma treatment: What has age got to do with it?


Clark, J and Zhu, Zhendan and Chuckowree, J and Dickson, T and Blizzard, C, Efficacy of epothilones in central nervous system trauma treatment: What has age got to do with it?, Neural Regeneration Research, 16, (4) pp. 618-620. ISSN 1673-5374 (2021) [Refereed Article]

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Copyright 2021, Wolters Kluwer Medknow Publications. This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, ( which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.

DOI: doi:10.4103/1673-5374.295312


Central nervous system injury, specifically traumatic brain and spinal cord injury, can have significant long lasting effects. There are no comprehensive treatments to combat the injury and sequalae of events that occurring following a central nervous system trauma. Herein we discuss the potential for the epothilone family of microtubule stabilizing agents to improve outcomes following experimentally induced trauma. These drugs, which are able to cross the blood-brain barrier, may hold great promise for the treatment of central nervous system trauma and the current literature presents the extensive range of beneficial effects these drugs may have following trauma in animal models. Importantly, the effect of the epothilones can vary and our most recent contributions to this field indicate that the efficacy of epothilones following traumatic brain injury is dependent upon the age of the animals. Therefore, we present a case for a greater emphasis to be placed upon age when using an intervention aimed at neural regeneration and highlight the importance of tailoring the therapeutic regime in the clinic to the age of the patient to promote improved patient outcomes.

Item Details

Item Type:Refereed Article
Keywords:aging, epothilones, glial, microtubule stablization, neuron, neuronal regeneration, spinal cord injury, traumatic brain injury
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Central nervous system
Objective Division:Health
Objective Group:Clinical health
Objective Field:Treatment of human diseases and conditions
UTAS Author:Clark, J (Mr Jayden Clark)
UTAS Author:Zhu, Zhendan (Mr Zhendan Zhu)
UTAS Author:Chuckowree, J (Dr Jyoti Chuckowree)
UTAS Author:Dickson, T (Professor Tracey Dickson)
UTAS Author:Blizzard, C (Professor Leigh Blizzard)
ID Code:147034
Year Published:2021
Web of Science® Times Cited:1
Deposited By:Menzies Institute for Medical Research
Deposited On:2021-10-11
Last Modified:2021-11-08
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