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Increased density of metallothionein I/II-immunopositive cortical glial cells in the early stages of Alzheimer's disease
Citation
Adlard, PA and West, AK and Vickers, JC, Increased density of metallothionein I/II-immunopositive cortical glial cells in the early stages of Alzheimer's disease, Neurobiology of Disease, 5, (5) pp. 349-356. ISSN 0969-9961 (1998) [Refereed Article]
DOI: doi:10.1006/nbdi.1998.0203
Abstract
We have examined the possible role of metallothionein I/II (MT I/II) in Alzheimer's disease (AD), with a focus on the cellular localization of MT I/II relative to the astrocyte marker, glial fibrillary acidic protein (GFAP). In AD and preclinical AD cases, MT I/II immunolabeling was present in glial cells and did not show a spatial relationship with β-amyloid plaques or neurofibrillary pathology. There was a six- to seven-fold increase in both MT I/II- and GFAP-labeled cells in the gray matter of AD cases, relative to non-AD cases. However, there was a threefold increase in MT I/II- immunoreactive cells, but not GFAP-labeled cells, in the gray matter of preclinical AD cases compared to non-AD cases. Therefore, the specific increase in MT I/II is associated with the initial stages of the disease process, perhaps due to oxidative stress or the mismetabolism of heavy metals.
Item Details
Item Type: | Refereed Article |
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Research Division: | Biomedical and Clinical Sciences |
Research Group: | Neurosciences |
Research Field: | Peripheral nervous system |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Adlard, PA (Dr Paul Anthony Adlard) |
UTAS Author: | West, AK (Professor Adrian West) |
UTAS Author: | Vickers, JC (Professor James Vickers) |
ID Code: | 14700 |
Year Published: | 1998 |
Web of Science® Times Cited: | 64 |
Deposited By: | Pathology |
Deposited On: | 1998-08-01 |
Last Modified: | 2011-08-09 |
Downloads: | 0 |
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