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Increased density of metallothionein I/II-immunopositive cortical glial cells in the early stages of Alzheimer's disease

Citation

Adlard, PA and West, AK and Vickers, JC, Increased density of metallothionein I/II-immunopositive cortical glial cells in the early stages of Alzheimer's disease, Neurobiology of Disease, 5, (5) pp. 349-356. ISSN 0969-9961 (1998) [Refereed Article]

DOI: doi:10.1006/nbdi.1998.0203

Abstract

We have examined the possible role of metallothionein I/II (MT I/II) in Alzheimer's disease (AD), with a focus on the cellular localization of MT I/II relative to the astrocyte marker, glial fibrillary acidic protein (GFAP). In AD and preclinical AD cases, MT I/II immunolabeling was present in glial cells and did not show a spatial relationship with β-amyloid plaques or neurofibrillary pathology. There was a six- to seven-fold increase in both MT I/II- and GFAP-labeled cells in the gray matter of AD cases, relative to non-AD cases. However, there was a threefold increase in MT I/II- immunoreactive cells, but not GFAP-labeled cells, in the gray matter of preclinical AD cases compared to non-AD cases. Therefore, the specific increase in MT I/II is associated with the initial stages of the disease process, perhaps due to oxidative stress or the mismetabolism of heavy metals.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Peripheral Nervous System
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:Adlard, PA (Dr Paul Anthony Adlard)
Author:West, AK (Professor Adrian West)
Author:Vickers, JC (Professor James Vickers)
ID Code:14700
Year Published:1998
Web of Science® Times Cited:52
Deposited By:Pathology
Deposited On:1998-08-01
Last Modified:2011-08-09
Downloads:0

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