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Familial and non-familial risk factors associated with incidence of colorectal cancer in young and middle-aged persons in Western Australia

journal contribution
posted on 2023-05-21, 03:01 authored by Kelty, E, Ward, SV, Cadby, G, McCarthy, NS, O'Leary, P, Eric MosesEric Moses, Ee, HC, Preen, DB

Aims: The aim of this study was to examine factors including family history, medical history and comorbidities associated with the risk of colorectal cancer (CRC) in young (18-49 years) and middle-age (50-69 years) individuals.

Methods: State records were used to identify individuals born in Western Australia between 1945 and 1996, and their first-degree relatives. Individuals in the cohort and their relatives were linked to State cancer registry, hospital and mortality data to identify diagnoses of CRC and other risk factors. The associations between CRC and identified risk factors were examined using multivariable logistic regression.

Results:For both young and middle-aged patients, family history of CRC, and a history of smoking, inflammatory bowel disease, liver disease and non-CRC cancer were associated with a significant increase in odds of CRC. In middle-aged patients, having a colonoscopy in the previous 10 years was associated with a reduced odds of CRC regardless of the detection of polyps. However, in young patients only the absence of polyps as confirmed by colonoscopy was associated with a decreased risk of CRC (OR: 0.38, 95%CI: 0.26 - 0.54, p < 0.001).

Conclusions: Many of the risk factors associated with CRC were similar in young and middle-aged persons, and should be used to identify high risk young patients for screening. The association between colonoscopy and polyps with CRC was modified by age, likely as the result of routine screening in middle-aged patients.

History

Publication title

Cancer Epidemiology

Volume

62

Pagination

1-6

ISSN

1877-7821

Department/School

Menzies Institute for Medical Research

Publisher

Elsevier

Place of publication

Netherlands

Rights statement

Copyright 2019 Elsevier Ltd.

Repository Status

  • Restricted

Socio-economic Objectives

Diagnosis of human diseases and conditions

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