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Furosemide compounds enhance urinary excretion of active kallikrein independently of their effects on urinary electrolyte excretion

Citation

Bulmer, BJ and Penschow, JD, Furosemide compounds enhance urinary excretion of active kallikrein independently of their effects on urinary electrolyte excretion, Experimental Nephrology, 6, (4) pp. 320-327. ISSN 1018-7782 (1998) [Refereed Article]

Abstract

The chemical and diuretic effects of furosemide on the excretion and activation of urinary prokallikrein were investigated in rats by treatment with furosemide compounds with a range of diuretic activity or amiloride hydrochloride or the vehicle. Diuresis occurred with furosemide and benzyl furosemide, but not with isofurosemide, amiloride hydrochloride, or the vehicle. The urinary excretion rate of active kallikrein was significantly elevated above controls throughout the 72 h of treatment with all of the drugs tested, regardless of the level of diuresis or the rate of urinary electrolyte excretion. In contrast, the urinary excretion rate of total kallikrein (prokallikrein + active kallikrein) was unchanged in all groups. These data indicate that furosemide derivatives increase the activation, but not the excretion, of urinary prokallikrein and that these effects are unrelated to the chemical structure or diuretic activity of the compounds or to overall changes in urinary electrolyte excretion rates.

Item Details

Item Type:Refereed Article
Research Division:Biological Sciences
Research Group:Biochemistry and Cell Biology
Research Field:Cell Metabolism
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Environmental Sciences
Author:Bulmer, BJ (Ms Bronwyn Jane Bulmer)
Author:Penschow, JD (Dr Jennifer Penschow)
ID Code:14698
Year Published:1998
Web of Science® Times Cited:1
Deposited By:Biochemistry
Deposited On:1998-08-01
Last Modified:2011-08-09
Downloads:0

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