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Experimental challenge models and in vitro models to investigate efficacy of treatments and vaccines against Amoebic Gill Disease

Citation

Hudson, J and Nowak, BF, Experimental challenge models and in vitro models to investigate efficacy of treatments and vaccines against Amoebic Gill Disease, Microorganisms, 9, (4) Article 710. ISSN 2076-2607 (2021) [Refereed Article]


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Copyright 2021 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

DOI: doi:10.3390/microorganisms9040710

Abstract

Amoebic Gill Disease (AGD) severely affects salmonid mariculture due to fish losses and costs associated with management of the disease. Continued research into management solutions, including new treatments and vaccine development, is highly important for the future of salmonid production worldwide. This requires both in vitro (both pathogen only and host-pathogen models) and in vivo (disease challenge) testing. Challenge models are still widely varied, in particular with regard to: infection methods (cohabitation or immersion), source of the pathogen (isolated from infected fish or cultured), infectious dose, environmental conditions (in particular temperature) and the endpoints across experimental treatment and vaccine studies which makes comparisons between studies difficult. This review summarises in vitro assays, the challenge methods and endpoints used in studies of experimental treatments and vaccines for AGD.

Item Details

Item Type:Refereed Article
Keywords:Amoebic Gill Disease, experimental infection, in vivo, in vitro, efficacy, Neoparamoeba perurans, vaccine testing, treatment testing
Research Division:Agricultural, Veterinary and Food Sciences
Research Group:Fisheries sciences
Research Field:Fish pests and diseases
Objective Division:Animal Production and Animal Primary Products
Objective Group:Fisheries - aquaculture
Objective Field:Aquaculture fin fish (excl. tuna)
UTAS Author:Hudson, J (Miss Jemma Hudson)
UTAS Author:Nowak, BF (Professor Barbara Nowak)
ID Code:146941
Year Published:2021
Deposited By:Fisheries and Aquaculture
Deposited On:2021-10-04
Last Modified:2021-12-13
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