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Is metformin use associated with a reduced risk of oesophageal cancer? A systematic review and meta-analysis


Chen, Y and Cheng, X and Sun, C and Kim, NH and Kailas, S and Qureshi, F and Karadsheh, Z and Wu, Y and Hu, L and Zhou, Z and Bhan, C and Kim, KY and Manem, R and Cheng, C and Zhou, Q, Is metformin use associated with a reduced risk of oesophageal cancer? A systematic review and meta-analysis, Postgraduate Medical Journal pp. 1-5. ISSN 0032-5473 (2021) [Refereed Article]

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Author(s) (or their employer(s)) 2021.

DOI: doi:10.1136/postgradmedj-2021-140432


Objectives: Studies on the association between metformin use and the risk of oesophageal cancer (OC) have generated controversial findings. This updated meta-analysis was conducted to reassess the effects of metformin on OC.

Methods: A comprehensive search strategy was conducted to select relevant studies from origination to February 2021. Heterogeneity was evaluated through the Q test and I2 statistics. HRs and 95% CIs were pooled through either random-effect or fixed-effect models. Meta-regression, subgroup analyses, sensitivity analysis and publication bias diagnosis were also performed.

Results: Seven studies with 5 426 343 subjects were included. Metformin use was associated with reduced risk of OC (HR=0.69, 95% CI 0.54 to 0.87, p<0.001). Sensitivity analysis suggested that the results were relatively stable.

Conclusion: Metformin is associated with a reduced risk of OC. More well-designed studies are still needed to further elaborate on these associations.

Item Details

Item Type:Refereed Article
Keywords:metformin, oesophageal cancer, meta-analysis
Research Division:Health Sciences
Research Group:Health services and systems
Research Field:Patient safety
Objective Division:Health
Objective Group:Clinical health
Objective Field:Efficacy of medications
UTAS Author:Zhou, Z (Dr Zhen Zhou)
ID Code:146889
Year Published:2021
Web of Science® Times Cited:1
Deposited By:Menzies Institute for Medical Research
Deposited On:2021-10-01
Last Modified:2022-08-15

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