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Within-visit SBP variability from childhood to adulthood and markers of cardiovascular end-organ damage in mid-life

Citation

Meng, Y and Magnussen, CG and Wu, F and Buscot, M-J and Juonala, M and Pahkala, K and Hutri-Kahonen, N and Kahonen, M and Laitinen, T and Viikari, JSA and Raitakari, OT and Sharman, JE, Within-visit SBP variability from childhood to adulthood and markers of cardiovascular end-organ damage in mid-life, Journal of Hypertension, 39, (9) pp. 1865-1875. ISSN 0263-6352 (2021) [Refereed Article]

DOI: doi:10.1097/HJH.0000000000002855

Abstract

Background: Within-visit SBP variability is associated with age and SBP, but its long-term clinical significance is unknown. We examined the association between child, adult, and life-time within-visit SBP variability with markers of end-organ damage using data from a 31-year longitudinal study.

Methods: Within-visit SBP variability was calculated as the standard deviation of three sitting SBP readings among up to 3010 participants aged 618 years (childhood) who were re-measured up to seven times to mid-adulthood. Markers of cardiovascular end-organ damage in adulthood were carotid intima--media thickness, brachial flow-mediated dilatation, carotid distensibility, pulse wave velocity, left ventricular mass index, carotid plaque, and coronary artery calcification.

Results: The mean (standard deviation) cumulative within-visit SBP variability was 2.7 (1.5) mmHg in childhood, 3.9 (1.9) mmHg in adulthood and 3.7 (1.5) mmHg across the observed life-time. Childhood within-visit SBP variability was not correlated with its subsequent values measured from 3 to 31 years later. With adjustment for age, sex, cumulative SBP, BMI and serum lipids, neither child, adult, or life-time cumulative within-visit SBP variability associated with markers of cardiovascular end-organ damage. However, higher child, adult, and life-time cumulative SBP significantly associated with higher carotid intima--media thickness, higher pulse wave velocity, lower brachial flow-mediated dilatation, lower carotid distensibility in adulthood.

Conclusion: Within-visit SBP variability from childhood to adulthood does not provide additional predictive utility over SBP over the same period of the life course.

Item Details

Item Type:Refereed Article
Keywords:blood pressure, hypertension, public health
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Cardiology (incl. cardiovascular diseases)
Objective Division:Health
Objective Group:Evaluation of health and support services
Objective Field:Determinants of health
UTAS Author:Meng, Y (Miss Yaxing Meng)
UTAS Author:Magnussen, CG (Associate Professor Costan Magnussen)
UTAS Author:Wu, F (Dr Feitong Wu)
UTAS Author:Buscot, M-J (Dr Marie-Jeanne Buscot)
UTAS Author:Sharman, JE (Professor James Sharman)
ID Code:146775
Year Published:2021
Deposited By:Menzies Institute for Medical Research
Deposited On:2021-09-24
Last Modified:2021-11-23
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