Meng, Y and Magnussen, CG and Wu, F and Buscot, M-J and Juonala, M and Pahkala, K and Hutri-Kahonen, N and Kahonen, M and Laitinen, T and Viikari, JSA and Raitakari, OT and Sharman, JE, Within-visit SBP variability from childhood to adulthood and markers of cardiovascular end-organ damage in mid-life, Journal of Hypertension, 39, (9) pp. 1865-1875. ISSN 0263-6352 (2021) [Refereed Article]
Background: Within-visit SBP variability is associated with age and SBP, but its long-term clinical significance is unknown. We examined the association between child, adult, and life-time within-visit SBP variability with markers of end-organ damage using data from a 31-year longitudinal study.
Methods: Within-visit SBP variability was calculated as the standard deviation of three sitting SBP readings among up to 3010 participants aged 6–18 years (childhood) who were re-measured up to seven times to mid-adulthood. Markers of cardiovascular end-organ damage in adulthood were carotid intima--media thickness, brachial flow-mediated dilatation, carotid distensibility, pulse wave velocity, left ventricular mass index, carotid plaque, and coronary artery calcification.
Results: The mean (standard deviation) cumulative within-visit SBP variability was 2.7 (1.5) mmHg in childhood, 3.9 (1.9) mmHg in adulthood and 3.7 (1.5) mmHg across the observed life-time. Childhood within-visit SBP variability was not correlated with its subsequent values measured from 3 to 31 years later. With adjustment for age, sex, cumulative SBP, BMI and serum lipids, neither child, adult, or life-time cumulative within-visit SBP variability associated with markers of cardiovascular end-organ damage. However, higher child, adult, and life-time cumulative SBP significantly associated with higher carotid intima--media thickness, higher pulse wave velocity, lower brachial flow-mediated dilatation, lower carotid distensibility in adulthood.
Conclusion: Within-visit SBP variability from childhood to adulthood does not provide additional predictive utility over SBP over the same period of the life course.
|Item Type:||Refereed Article|
|Keywords:||blood pressure, hypertension, public health|
|Research Division:||Biomedical and Clinical Sciences|
|Research Group:||Cardiovascular medicine and haematology|
|Research Field:||Cardiology (incl. cardiovascular diseases)|
|Objective Group:||Evaluation of health and support services|
|Objective Field:||Determinants of health|
|UTAS Author:||Meng, Y (Miss Yaxing Meng)|
|UTAS Author:||Magnussen, CG (Associate Professor Costan Magnussen)|
|UTAS Author:||Wu, F (Dr Feitong Wu)|
|UTAS Author:||Buscot, M-J (Dr Marie-Jeanne Buscot)|
|UTAS Author:||Sharman, JE (Professor James Sharman)|
|Web of Science® Times Cited:||1|
|Deposited By:||Menzies Institute for Medical Research|
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