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Health-related quality of life and incident cardiovascular disease events in community-dwelling older people: A prospective cohort study


Phyo, AZZ and Ryan, J and Gonzalez-Chica, DA and Stocks, NP and Reid, CM and Tonkin, AM and Woods, RL and Nelson, MR and Murray, AM and Gasevic, D and Freak-Poli, R, ASPREE Investigator Group, Health-related quality of life and incident cardiovascular disease events in community-dwelling older people: A prospective cohort study, International Journal of Cardiology, 339 pp. 170-178. ISSN 0167-5273 (2021) [Refereed Article]

Copyright Statement

2021 Elsevier B.V. All rights reserved.

DOI: doi:10.1016/j.ijcard.2021.07.004


Background: Lower health-related quality of life (HRQoL) has been shown to predict a higher risk of hospital readmission and mortality in patients with cardiovascular disease (CVD). Few studies have explored the associations between HRQoL and incident CVD. We explored the associations between baseline HRQoL and incident and fatal CVD in community-dwelling older people in Australia and the United States.

Methods: Longitudinal study using ASPirin in Reducing Events in the Elderly (ASPREE) trial data. This includes 19,106 individuals aged 65-98 years, initially free of CVD, dementia, or disability, and followed between March 2010 and June 2017. The physical (PCS) and mental component scores (MCS) of HRQoL were assessed using the SF-12 questionnaire. Incident major adverse CVD events included fatal CVD (death due to atherothrombotic CVD), hospitalizations for heart failure, myocardial infarction or stroke. Analyses were performed using Cox proportional-hazard regression.

Results: Over a median 4.7 follow-up years, there were 922 incident CVD events, 203 fatal CVD events, 171 hospitalizations for heart failure, 355 fatal or nonfatal myocardial infarction and 403 fatal or nonfatal strokes. After adjustment for sociodemographic, health-related behaviours and clinical measures, a 10-unit higher PCS, but not MCS, was associated with a 14% lower risk of incident CVD, 28% lower risk of hospitalization for heart failure and 15% lower risk of myocardial infarction. Neither PCS nor MCS was associated with fatal CVD events or stroke.

Conclusion: Physical HRQoL can be used in combination with clinical data to identify the incident CVD risk among older individuals.

Item Details

Item Type:Refereed Article
Keywords:aged, cardiovascular diseases, incidence, quality of life, risk factors
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Cardiology (incl. cardiovascular diseases)
Objective Division:Health
Objective Group:Evaluation of health and support services
Objective Field:Evaluation of health outcomes
UTAS Author:Nelson, MR (Professor Mark Nelson)
ID Code:146756
Year Published:2021
Web of Science® Times Cited:8
Deposited By:Medicine
Deposited On:2021-09-24
Last Modified:2022-08-25

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