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The potential roles of genetic factors in predicting ageing-related cognitive change and Alzheimer's disease
Citation
Pan, G and King, A and Wu, F and Simpson-Yap, S and Woodhouse, A and Phipps, A and Vickers, JC, The potential roles of genetic factors in predicting ageing-related cognitive change and Alzheimer's disease, Ageing Research Reviews, 70 pp. 1-15. ISSN 1568-1637 (2021) [Refereed Article]
Copyright Statement
© 2021 Published by Elsevier B.V.
DOI: doi:10.1016/j.arr.2021.101402
Abstract
Alzheimer's disease (AD) is a complex neurological disorder of uncertain aetiology, although substantial research has been conducted to explore important factors related to risk of onset and progression. Both lifestyle (e.g., complex mental stimulation, vascular health) and genetic factors (e.g., APOE, BDNF, PICALM, CLU, APP, PSEN1, PSEN2, and other genes) have been associated with AD risk. Despite more than thirty years of genetic research, much of the heritability of AD is not explained by measured loci. This suggests that the missing heritability of AD might be potentially related to rare variants, gene-environment and gene-gene interactions, and potentially epigenetic modulators. Moreover, while ageing is the most substantial factor risk for AD, there are limited longitudinal studies examining the association of genetic factors with decline in cognitive function due to ageing and the preclinical stages of this condition. This review summarises findings from currently available research on the genetic factors of ageing-related cognitive change and AD and suggests some future research directions.
Item Details
Item Type: | Refereed Article |
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Keywords: | APOE, Alzheimer's disease, cognitive decline, cognitive function, genetics, PRS. polygenic risk score |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Neurosciences |
Research Field: | Neurology and neuromuscular diseases |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Diagnosis of human diseases and conditions |
UTAS Author: | Pan, G (Mr Gongbu Pan) |
UTAS Author: | King, A (Professor Anna King) |
UTAS Author: | Wu, F (Dr Feitong Wu) |
UTAS Author: | Simpson-Yap, S (Dr Steve Simpson JR) |
UTAS Author: | Woodhouse, A (Dr Adele Woodhouse) |
UTAS Author: | Vickers, JC (Professor James Vickers) |
ID Code: | 146741 |
Year Published: | 2021 |
Web of Science® Times Cited: | 2 |
Deposited By: | Wicking Dementia Research and Education Centre |
Deposited On: | 2021-09-23 |
Last Modified: | 2021-10-18 |
Downloads: | 0 |
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