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Rutin-loaded liquid crystalline nanoparticles attenuate oxidative stress in bronchial epithelial cells: A PCR validation

Citation

Mehta, M and Paudel, KR and Shukla, SD and Shastri, MD and Satija, S and Singh, SK and Gulati, M and Dureja, H and Zacconi, FC and Hansbro, PM and Chellappan, DK and Dua, K, Rutin-loaded liquid crystalline nanoparticles attenuate oxidative stress in bronchial epithelial cells: A PCR validation, Future Medicinal Chemistry, 13, (6) pp. 543-549. ISSN 1756-8919 (2021) [Refereed Article]

DOI: doi:10.4155/fmc-2020-0297

Abstract

Aim: In the present study, the inhibitory potential of rutin-loaded liquid crystalline nanoparticles (LCNs) on oxidative stress was determined in human bronchial epithelial cells (BEAS-2B) by analysing the expression levels of different antioxidant (NADPH quinine oxidoreductase-1 (NQO1); γ-glutamyl cysteine synthetase catalytic subunit (GCLC)) and pro-oxidant (NADPH oxidase (Nox)-4; Nox2B) genes.

Results: Our findings revealed that the rutin-loaded LCNs inhibited the genes, namely Nox2B and Nox4, which caused oxidative stress. In addition, these nanoparticles demonstrated an upregulation in the expression of the antioxidant genes Gclc and Nqo-1 in a dose-dependent manner.

Conclusion: The study indicates the promising potential of rutin-loaded LCNs as an effective treatment strategy in patients with high oxidant loads in various respiratory diseases.

Item Details

Item Type:Refereed Article
Keywords:antioxidant, inflammation, lipopolysaccharide, oxidative stress genes, rutin
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Respiratory diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Treatment of human diseases and conditions
UTAS Author:Shastri, MD (Mr Madhur Shastri)
ID Code:146735
Year Published:2021
Web of Science® Times Cited:4
Deposited By:Health Sciences
Deposited On:2021-09-23
Last Modified:2021-09-23
Downloads:0

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