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Rutin-loaded liquid crystalline nanoparticles attenuate oxidative stress in bronchial epithelial cells: A PCR validation
Citation
Mehta, M and Paudel, KR and Shukla, SD and Shastri, MD and Satija, S and Singh, SK and Gulati, M and Dureja, H and Zacconi, FC and Hansbro, PM and Chellappan, DK and Dua, K, Rutin-loaded liquid crystalline nanoparticles attenuate oxidative stress in bronchial epithelial cells: A PCR validation, Future Medicinal Chemistry, 13, (6) pp. 543-549. ISSN 1756-8919 (2021) [Refereed Article]
DOI: doi:10.4155/fmc-2020-0297
Abstract
Aim: In the present study, the inhibitory potential of rutin-loaded liquid crystalline nanoparticles (LCNs) on oxidative stress was determined in human bronchial epithelial cells (BEAS-2B) by analysing the expression levels of different antioxidant (NADPH quinine oxidoreductase-1 (NQO1); γ-glutamyl cysteine synthetase catalytic subunit (GCLC)) and pro-oxidant (NADPH oxidase (Nox)-4; Nox2B) genes.
Results: Our findings revealed that the rutin-loaded LCNs inhibited the genes, namely Nox2B and Nox4, which caused oxidative stress. In addition, these nanoparticles demonstrated an upregulation in the expression of the antioxidant genes Gclc and Nqo-1 in a dose-dependent manner.
Conclusion: The study indicates the promising potential of rutin-loaded LCNs as an effective treatment strategy in patients with high oxidant loads in various respiratory diseases.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | antioxidant, inflammation, lipopolysaccharide, oxidative stress genes, rutin |
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Cardiovascular medicine and haematology |
| Research Field: | Respiratory diseases |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Treatment of human diseases and conditions |
| UTAS Author: | Shastri, MD (Mr Madhur Shastri) |
| ID Code: | 146735 |
| Year Published: | 2021 |
| Web of Science® Times Cited: | 12 |
| Deposited By: | Health Sciences |
| Deposited On: | 2021-09-23 |
| Last Modified: | 2022-08-25 |
| Downloads: | 0 |
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