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Rutin-loaded liquid crystalline nanoparticles attenuate oxidative stress in bronchial epithelial cells: A PCR validation
Mehta, M and Paudel, KR and Shukla, SD and Shastri, MD and Satija, S and Singh, SK and Gulati, M and Dureja, H and Zacconi, FC and Hansbro, PM and Chellappan, DK and Dua, K, Rutin-loaded liquid crystalline nanoparticles attenuate oxidative stress in bronchial epithelial cells: A PCR validation, Future Medicinal Chemistry, 13, (6) pp. 543-549. ISSN 1756-8919 (2021) [Refereed Article]
Aim: In the present study, the inhibitory potential of rutin-loaded liquid crystalline nanoparticles (LCNs) on oxidative stress was determined in human bronchial epithelial cells (BEAS-2B) by analysing the expression levels of different antioxidant (NADPH quinine oxidoreductase-1 (NQO1); γ-glutamyl cysteine synthetase catalytic subunit (GCLC)) and pro-oxidant (NADPH oxidase (Nox)-4; Nox2B) genes.
Results: Our findings revealed that the rutin-loaded LCNs inhibited the genes, namely Nox2B and Nox4, which caused oxidative stress. In addition, these nanoparticles demonstrated an upregulation in the expression of the antioxidant genes Gclc and Nqo-1 in a dose-dependent manner.
Conclusion: The study indicates the promising potential of rutin-loaded LCNs as an effective treatment strategy in patients with high oxidant loads in various respiratory diseases.
|Item Type:||Refereed Article|
|Keywords:||antioxidant, inflammation, lipopolysaccharide, oxidative stress genes, rutin|
|Research Division:||Biomedical and Clinical Sciences|
|Research Group:||Cardiovascular medicine and haematology|
|Research Field:||Respiratory diseases|
|Objective Group:||Clinical health|
|Objective Field:||Treatment of human diseases and conditions|
|UTAS Author:||Shastri, MD (Mr Madhur Shastri)|
|Web of Science® Times Cited:||12|
|Deposited By:||Health Sciences|
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