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Macular thickness profile and its association with best-corrected visual acuity in healthy young adults


Lee, SSY and Lingham, G and Alonso-Caneiro, D and Charng, J and Chen, FK and Yazar, S and Mackey, DA, Macular thickness profile and its association with best-corrected visual acuity in healthy young adults, Translational Vision Science and Technology, 10, (3) pp. 1-11. ISSN 2164-2591 (2021) [Refereed Article]

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Copyright 2021 The Authors. This work is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) License, (

DOI: doi:10.1167/tvst.10.3.8


Purpose: To describe the thickness profiles of the full retinal and outer retinal layers (ORL) at the macula in healthy young adults, and associations with best-corrected visual acuity (BCVA).

Methods: In total, 1604 participants (19-30 years) underwent an eye examination that included measurements of their BCVA, axial length, and autorefraction. The retinal thickness at the foveal pit and at the nine Early Treatment of Diabetic Retinopathy Study macular regions (0.5-mm radius around the fovea, and superior, inferior, temporal, and nasal quadrants of the inner and outer rings of the macula) were obtained using spectral-domain optical coherence tomography imaging. A custom program was used to correct for transverse magnification effects because of different axial lengths.

Results: The median full retinal and ORL thicknesses at the central macula were 285 Ám and 92 Ám. The full retina was thinnest centrally and thickest at the inner macula ring, whereas the ORL was thickest centrally and gradually decreased in thickness with increasing eccentricity. There was no association between axial length and the full retinal or ORL thickness. Increased thicknesses of the full retina at the central macula was associated with better BCVA; however, the effect size was small and not clinically significant.

Conclusions: This article mapped the full retinal and ORL thickness profile in a population-based sample of young healthy adults.

Translational relevance: Thickness values presented in this article could be used as a normative reference for future studies on young adults and in clinical practice.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Ophthalmology and optometry
Research Field:Ophthalmology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Treatment of human diseases and conditions
UTAS Author:Mackey, DA (Professor David Mackey)
ID Code:146693
Year Published:2021
Web of Science® Times Cited:5
Deposited By:Menzies Institute for Medical Research
Deposited On:2021-09-22
Last Modified:2021-10-20
Downloads:10 View Download Statistics

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