eCite Digital Repository
Signal intensity alteration and maximal area of pericruciate fat pad are associated with incident radiographic osteoarthritis: data from the Osteoarthritis Initiative
Citation
Li, Y and Li, J and Zhu, Z and Cao, P and Han, W and Ruan, G and Fan, T and Hunter, DJ and Ding, C, Signal intensity alteration and maximal area of pericruciate fat pad are associated with incident radiographic osteoarthritis: data from the Osteoarthritis Initiative, European Radiology ISSN 0938-7994 (2021) [Refereed Article]
Copyright Statement
Copyright European Society of Radiology 2021
DOI: doi:10.1007/s00330-021-08193-1
Abstract
Objective: To determine whether pericruciate fat pad (PCFP) signal intensity alteration and maximal area are associated with incident radiographic osteoarthritis (ROA) over 4 years in the Osteoarthritis Initiative (OAI) study.
Methods: Participants were from the Osteoarthritis Initiative (OAI) study. Case knees (n = 355) were defined by incident ROA between 12 and 48 months visits and were matched by sex, age, and radiographic status with control knees (n = 355). Magnetic resonance images (MRIs) were used to assess PCFP signal intensity alteration and PCFP maximal area at P0 (time of onset of ROA), P-1 (1 year prior to P0), and baseline. Conditional logistic regression analyses were applied to assess associations between PCFP measures and the risk of incident ROA.
Results: The mean age of participants was 60.1 years and 66.9% were women. In multivariable analyses, PCFP signal intensity alteration measured at three time points (OR [95%CI]: 1.28 [1.10-1.50], 1.52 [1.30-1.78], 1.50 [1.27-1.76], respectively) and PCFP maximal area (OR [95%CI]: 1.21 [1.03-1.42], 1.27 [1.07-1.52], 1.37 [1.15-1.62], respectively) were significantly associated with incident ROA.
Conclusions: PCFP signal intensity alteration and maximal area were associated with incident ROA over 4 years, implying that they may have roles to play in ROA.
Item Details
Item Type: | Refereed Article |
---|---|
Keywords: | adipose tissue, magnetic resonance imaging, osteoarthritis, knee |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Clinical sciences |
Research Field: | Radiology and organ imaging |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Diagnosis of human diseases and conditions |
UTAS Author: | Ding, C (Professor Chang-Hai Ding) |
ID Code: | 146666 |
Year Published: | 2021 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2021-09-21 |
Last Modified: | 2021-11-15 |
Downloads: | 0 |
Repository Staff Only: item control page