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Circadian biology and stroke


Lo, EH and Albers, GW and Dichgans, M and Donnan, G and Esposito, E and Foster, R and Howells, DW and Huang, YG and Ji, X and Klerman, EB and Lee, S and Li, W and Liebeskind, DS and Lizasoain, I and Mandeville, ET and Moro, MA and Ning, M and Ray, D and Sakadzic, S and Saver, JL and Scheer, FAJL and Selim, M and Tiedt, S and Zhang, F and Buchan, AM, Circadian biology and stroke, Stroke, 52, (6) pp. 2180-2190. ISSN 0039-2499 (2021) [Refereed Article]

DOI: doi:10.1161/STROKEAHA.120.031742


Circadian biology modulates almost all aspects of mammalian physiology, disease, and response to therapies. Emerging data suggest that circadian biology may significantly affect the mechanisms of susceptibility, injury, recovery, and the response to therapy in stroke. In this review/perspective, we survey the accumulating literature and attempt to connect molecular, cellular, and physiological pathways in circadian biology to clinical consequences in stroke. Accounting for the complex and multifactorial effects of circadian rhythm may improve translational opportunities for stroke diagnostics and therapeutics.

Item Details

Item Type:Refereed Article
Keywords:biomarkers, circadian rhythm, immune system, ischemia, neuroprotection, sleep
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Central nervous system
Objective Division:Health
Objective Group:Clinical health
Objective Field:Treatment of human diseases and conditions
UTAS Author:Howells, DW (Professor David Howells)
ID Code:146663
Year Published:2021
Web of Science® Times Cited:16
Deposited By:Medicine
Deposited On:2021-09-21
Last Modified:2022-08-23

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