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Circadian biology and stroke
journal contribution
posted on 2023-05-21, 02:34 authored by Lo, EH, Albers, GW, Dichgans, M, Donnan, G, Esposito, E, Foster, R, David Howells, Huang, YG, Ji, X, Klerman, EB, Lee, S, Li, W, Liebeskind, DS, Lizasoain, I, Mandeville, ET, Moro, MA, Ning, M, Ray, D, Sakadzic, S, Saver, JL, Scheer, FAJL, Selim, M, Tiedt, S, Zhang, F, Buchan, AMCircadian biology modulates almost all aspects of mammalian physiology, disease, and response to therapies. Emerging data suggest that circadian biology may significantly affect the mechanisms of susceptibility, injury, recovery, and the response to therapy in stroke. In this review/perspective, we survey the accumulating literature and attempt to connect molecular, cellular, and physiological pathways in circadian biology to clinical consequences in stroke. Accounting for the complex and multifactorial effects of circadian rhythm may improve translational opportunities for stroke diagnostics and therapeutics.
History
Publication title
StrokeVolume
52Issue
6Pagination
2180-2190ISSN
0039-2499Department/School
Tasmanian School of MedicinePublisher
Lippincott Williams & WilkinsPlace of publication
United StatesRepository Status
- Restricted