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Circadian biology and stroke
Citation
Lo, EH and Albers, GW and Dichgans, M and Donnan, G and Esposito, E and Foster, R and Howells, DW and Huang, YG and Ji, X and Klerman, EB and Lee, S and Li, W and Liebeskind, DS and Lizasoain, I and Mandeville, ET and Moro, MA and Ning, M and Ray, D and Sakadzic, S and Saver, JL and Scheer, FAJL and Selim, M and Tiedt, S and Zhang, F and Buchan, AM, Circadian biology and stroke, Stroke, 52, (6) pp. 2180-2190. ISSN 0039-2499 (2021) [Refereed Article]
DOI: doi:10.1161/STROKEAHA.120.031742
Abstract
Circadian biology modulates almost all aspects of mammalian physiology, disease, and response to therapies. Emerging data suggest that circadian biology may significantly affect the mechanisms of susceptibility, injury, recovery, and the response to therapy in stroke. In this review/perspective, we survey the accumulating literature and attempt to connect molecular, cellular, and physiological pathways in circadian biology to clinical consequences in stroke. Accounting for the complex and multifactorial effects of circadian rhythm may improve translational opportunities for stroke diagnostics and therapeutics.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | biomarkers, circadian rhythm, immune system, ischemia, neuroprotection, sleep |
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Neurosciences |
| Research Field: | Central nervous system |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Treatment of human diseases and conditions |
| UTAS Author: | Howells, DW (Professor David Howells) |
| ID Code: | 146663 |
| Year Published: | 2021 |
| Web of Science® Times Cited: | 16 |
| Deposited By: | Medicine |
| Deposited On: | 2021-09-21 |
| Last Modified: | 2022-08-23 |
| Downloads: | 0 |
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