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Association Between Components of Cognitive Reserve and Serum BDNF in Healthy Older Adults

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Collins, JM and Hill, E and Bindoff, A and King, AE and Alty, J and Summers, MJ and Vickers, JC, Association Between Components of Cognitive Reserve and Serum BDNF in Healthy Older Adults, Frontiers in Aging Neuroscience, 13 pp. 1-9. ISSN 1663-4365 (2021) [Refereed Article]


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Copyright Statement

Copyright © 2021 Collins, Hill, Bindoff, King, Alty, Summers and Vickers. This article is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) License, (https://creativecommons.org/licenses/by/4.0/), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

DOI: doi:10.3389/fnagi.2021.725914

Abstract

Background: The brain-derived neurotrophic factor (BDNF) protein has been shown to have a prominent role in neuron survival, growth, and function in experimental models, and the BDNFVal66Met polymorphism which regulates its expression has been linked to resilience toward the effects of aging on cognition. Cognitively stimulating activity is linked to both increased levels of BDNF in the brain, and protection against age-related cognitive decline. The aim of this study was to investigate the associations between serum BDNF levels, the BDNF Val66Met genotype, and components of cognitive reserve in early and mid-life, measured with the Lifetime of Experiences Questionnaire (LEQ).

Methods: Serum BDNF levels were measured cross-sectionally in 156 participants from the Tasmanian Healthy Brain Project (THBP) cohort, a study examining the potential benefits of older adults engaging in a university-level education intervention. Multiple linear regression was used to estimate serum BDNF’s association with age, education, gender, BDNF Val66Met genotype, later-life university-level study, and cognitively stimulating activities measured by the LEQ.

Results: Serum BDNF in older adults was associated with early life education and training, increasing 0.007 log(pg/ml) [95%CI 0.001, 0.012] per unit on the LEQ subscale. Conversely, education and training in mid-life were associated with a −0.007 log(pg/ml) [−0.012, −0.001] decrease per unit on the LEQ subscale. Serum BDNF decreased with age (−0.008 log(pg/ml) [−0.015, −0.001] per year), and male gender (−0.109 log(pg/ml) [−0.203, −0.015]), but mean differences between the BDNF Val66Met polymorphisms were not significant (p = 0.066). All effect sizes were small, with mid-life education and training having the largest effect size ( η p 2 = 0.044).

Conclusion: Education in both early and mid-life explained small but significant amounts of variance in serum BDNF levels, more than age or gender. These effects were opposed and independent, suggesting that education at different stages of life may be associated with different cognitive and neural demands. Education at different stages of life may be important covariates when estimating associations between other exposures and serum BDNF.

Item Details

Item Type:Refereed Article
Keywords:Alzheimer’s disease, biomarkers, brain derived neurotrophic factor, cognitive reserve, education, polymorphism, serum
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Central nervous system
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Preventive medicine
UTAS Author:Collins, JM (Dr Jessica Collins)
UTAS Author:Hill, E (Dr Edward Hill)
UTAS Author:Bindoff, A (Mr Aidan Bindoff)
UTAS Author:King, AE (Professor Anna King)
UTAS Author:Alty, J (Dr Jane Alty)
UTAS Author:Summers, MJ (Dr Mathew Summers)
UTAS Author:Vickers, JC (Professor James Vickers)
ID Code:146598
Year Published:2021
Deposited By:Wicking Dementia Research and Education Centre
Deposited On:2021-09-15
Last Modified:2021-10-14
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