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Regulation of ecdysone production in Drosophila by neuropeptides and peptide hormones
Citation
Kannangara, JR and Mirth, CK and Warr, CG, Regulation of ecdysone production in Drosophila by neuropeptides and peptide hormones, Open Biology, 11, (2) pp. 1-11. ISSN 2046-2441 (2021) [Refereed Article]
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Copyright Statement
© 2021 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) License, http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
Abstract
In both mammals and insects, steroid hormones play a major role in
directing the animal’s progression through developmental stages. To maximize fitness outcomes, steroid hormone production is regulated by the
environmental conditions experienced by the animal. In insects, the steroid
hormone ecdysone mediates transitions between developmental stages and
is regulated in response to environmental factors such as nutrition. These
environmental signals are communicated to the ecdysone-producing gland
via the action of neuropeptide and peptide hormone signalling pathways.
While some of these pathways have been well characterized, there is evidence to suggest more signalling pathways than has previously been
thought function to control ecdysone production, potentially in response
to a greater range of environmental conditions. Here, we review the neuropeptide and peptide hormone signalling pathways known to regulate the
production of ecdysone in the model genetic insect Drosophila melanogaster,
as well as what is known regarding the environmental signals that trigger
these pathways. Areas for future research are highlighted that can further
contribute to our overall understanding of the complex orchestration of
environmental, physiological and developmental cues that together produce
a functioning adult organism.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | Drosophila melanogaster, development, ecdysone, growth, neuropeptides, signalling |
| Research Division: | Biological Sciences |
| Research Group: | Genetics |
| Research Field: | Neurogenetics |
| Objective Division: | Expanding Knowledge |
| Objective Group: | Expanding knowledge |
| Objective Field: | Expanding knowledge in the biological sciences |
| UTAS Author: | Warr, CG (Professor Coral Warr) |
| ID Code: | 146458 |
| Year Published: | 2021 |
| Web of Science® Times Cited: | 7 |
| Deposited By: | Medicine |
| Deposited On: | 2021-09-08 |
| Last Modified: | 2021-10-26 |
| Downloads: | 3 View Download Statistics |
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