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Revisiting mitochondria scored cancer progression and metastasis


Gundamaraju, R and LU, W and Manikam, R, Revisiting mitochondria scored cancer progression and metastasis, Cancers, 13, (3) pp. 1-13. ISSN 2072-6694 (2021) [Refereed Article]

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Copyright: 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons 4.0 International (CC BY 4.0) license (

DOI: doi:10.3390/cancers13030432


The Warburg effect has immensely succored the study of cancer biology, especially in highlighting the role of mitochondria in cancer stemness and their benefaction to the malignancy of oxidative and glycolytic cancer cells. Mitochondrial genetics have represented a focal point in cancer therapeutics due to the involvement of mitochondria in programmed cell death. The mitochondrion has been well established as a switch in cell death decisions. The mitochondrion's instrumental role in central bioenergetics, calcium homeostasis, and translational regulation has earned it its fame in metastatic dissemination in cancer cells. Here, we revisit and review mechanisms through which mitochondria influence oncogenesis and metastasis by underscoring the oncogenic mitochondrion that is capable of transferring malignant capacities to recipient cells.

Item Details

Item Type:Refereed Article
Keywords:OXPHOS, Warburg effect, cancer, cancer therapeutics, metastasis, mitochondria
Research Division:Biomedical and Clinical Sciences
Research Group:Oncology and carcinogenesis
Research Field:Cancer cell biology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Diagnosis of human diseases and conditions
UTAS Author:Gundamaraju, R (Mr Rohit Gundamaraju)
UTAS Author:LU, W (Dr Monica Lu)
ID Code:146428
Year Published:2021
Web of Science® Times Cited:4
Deposited By:Health Sciences
Deposited On:2021-09-07
Last Modified:2022-08-29
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