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Characterisation of a type IV pilus produced by Aeromonas caviae
Citation
Kirov, SM and Sanderson, K and Dickson, TC, Characterisation of a type IV pilus produced by Aeromonas caviae, Journal of Medical Microbiology, 47, (6) pp. 527-531. ISSN 0022-2615 (1998) [Refereed Article]
DOI: doi:10.1099/00222615-47-6-527
Abstract
A pilus produced by a clinical isolate of Aeromanas caviae (strain CA195) was purified and partially characterised. The M(r) of the pilin was estimated to be 23 kDa by SDS-PAGE. Its N-terminal amino-acid sequence showed that it was closely related to 'bundle-forming' type IV pili purified from other Aeromonas spp. associated with gastro-enteritis and considered to be important intestinal colonisation factors. Bundle-forming pili, often with a polar location, were seen on the surface of strain CA195 which was highly adherent to HEp-2 cells. Removal of surface structures by mechanical means decreased adhesion (by ≤ 50%) suggesting that these pill played some role in HEp-2 cell binding. This pilus type could prove an important marker for enteropathogenic A. caviae which appear to lack other putative virulence factors.
Item Details
Item Type: | Refereed Article |
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Research Division: | Biomedical and Clinical Sciences |
Research Group: | Medical microbiology |
Research Field: | Medical bacteriology |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Kirov, SM (Associate Professor Sylvia Kirov) |
UTAS Author: | Sanderson, K (Dr Kevin Sanderson) |
UTAS Author: | Dickson, TC (Professor Tracey Dickson) |
ID Code: | 14640 |
Year Published: | 1998 |
Web of Science® Times Cited: | 16 |
Deposited By: | Pathology |
Deposited On: | 1998-08-01 |
Last Modified: | 2011-08-09 |
Downloads: | 0 |
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