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Characterisation of a type IV pilus produced by Aeromonas caviae

Citation

Kirov, SM and Sanderson, K and Dickson, TC, Characterisation of a type IV pilus produced by Aeromonas caviae, Journal of Medical Microbiology, 47, (6) pp. 527-531. ISSN 0022-2615 (1998) [Refereed Article]

DOI: doi:10.1099/00222615-47-6-527

Abstract

A pilus produced by a clinical isolate of Aeromanas caviae (strain CA195) was purified and partially characterised. The M(r) of the pilin was estimated to be 23 kDa by SDS-PAGE. Its N-terminal amino-acid sequence showed that it was closely related to 'bundle-forming' type IV pili purified from other Aeromonas spp. associated with gastro-enteritis and considered to be important intestinal colonisation factors. Bundle-forming pili, often with a polar location, were seen on the surface of strain CA195 which was highly adherent to HEp-2 cells. Removal of surface structures by mechanical means decreased adhesion (by ≤ 50%) suggesting that these pill played some role in HEp-2 cell binding. This pilus type could prove an important marker for enteropathogenic A. caviae which appear to lack other putative virulence factors.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Medical Microbiology
Research Field:Medical Bacteriology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Infectious Diseases
Author:Kirov, SM (Associate Professor Sylvia Kirov)
Author:Sanderson, K (Dr Kevin Sanderson)
Author:Dickson, TC (Associate Professor Tracey Dickson)
ID Code:14640
Year Published:1998
Web of Science® Times Cited:15
Deposited By:Pathology
Deposited On:1998-08-01
Last Modified:2011-08-09
Downloads:0

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