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Adjuvant pitolisant in a case with early-onset schizophrenia
Citation
Naguy, A and Pridmore, S and Alamiri, B, Adjuvant pitolisant in a case with early-onset schizophrenia, Clinical Neuropharmacology ISSN 0362-5664 (2021) [Contribution to Refereed Journal]
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DOI: doi:10.1097/WNF.0000000000000472
Abstract
Objectives: Early-onset schizophrenia is notorious for poor prognostication and treatment refractoriness. Child/adolescent psychiatric population, by virtue of age, is at a heightened risk for cardiometabolic risk of atypical antipsychotics. Available pharmacological options are, sorely, too limited to mitigate this risk.
Methods: The authors are reporting here on an adolescent case with early-onset schizophrenia who has favorably responded to olanzapine but with problematic weight gain that failed a trial of add-on metformin. A trial of add-on pitolisant was pursued.
Results: Adjunctive pitolisant has successfully helped with the weight issue. Strikingly, there were parallel improvements in both cognitive and negative domains as well.
Conclusions:Add-on pitolisant can be a safe and effective strategy to address antipsychotic-induced metabolic syndrome. Gains might also span negative/cognitive domains. This might open new treatment venues for such complicated clinical scenarios that await replication in larger rigorous studies.
Item Details
Item Type: | Contribution to Refereed Journal |
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Research Division: | Biomedical and Clinical Sciences |
Research Group: | Clinical sciences |
Research Field: | Psychiatry (incl. psychotherapy) |
Objective Division: | Health |
Objective Group: | Public health (excl. specific population health) |
Objective Field: | Mental health |
UTAS Author: | Pridmore, S (Professor Saxby Pridmore) |
ID Code: | 146373 |
Year Published: | 2021 |
Deposited By: | Medicine |
Deposited On: | 2021-09-02 |
Last Modified: | 2021-09-02 |
Downloads: | 0 |
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