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Adjuvant pitolisant in a case with early-onset schizophrenia


Naguy, A and Pridmore, S and Alamiri, B, Adjuvant pitolisant in a case with early-onset schizophrenia, Clinical Neuropharmacology ISSN 0362-5664 (2021) [Contribution to Refereed Journal]

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DOI: doi:10.1097/WNF.0000000000000472


Objectives: Early-onset schizophrenia is notorious for poor prognostication and treatment refractoriness. Child/adolescent psychiatric population, by virtue of age, is at a heightened risk for cardiometabolic risk of atypical antipsychotics. Available pharmacological options are, sorely, too limited to mitigate this risk.

Methods: The authors are reporting here on an adolescent case with early-onset schizophrenia who has favorably responded to olanzapine but with problematic weight gain that failed a trial of add-on metformin. A trial of add-on pitolisant was pursued.

Results: Adjunctive pitolisant has successfully helped with the weight issue. Strikingly, there were parallel improvements in both cognitive and negative domains as well.

Conclusions:Add-on pitolisant can be a safe and effective strategy to address antipsychotic-induced metabolic syndrome. Gains might also span negative/cognitive domains. This might open new treatment venues for such complicated clinical scenarios that await replication in larger rigorous studies.

Item Details

Item Type:Contribution to Refereed Journal
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Psychiatry (incl. psychotherapy)
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Mental health
UTAS Author:Pridmore, S (Professor Saxby Pridmore)
ID Code:146373
Year Published:2021
Deposited By:Medicine
Deposited On:2021-09-02
Last Modified:2021-09-02

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