eCite Digital Repository

Pseudomonas aeruginosa as a cause of infectious diarrhoea

Citation

Adlard, PA and Kirov, SM and Sanderson, K and Cox, GE, Pseudomonas aeruginosa as a cause of infectious diarrhoea, Epidemiology and Infection, 121, (1) pp. 237-241. ISSN 0950-2688 (1998) [Refereed Article]

DOI: doi:10.1017/S095026889800106X

Abstract

Pseudomonas aeruginosa is not generally considered a cause of infectious diarrhoea. However, it was the predominant organism isolated from the faeces of 23 unrelated, hospital outpatients investigated in the course of a year for persistent (> 1 week duration) diarrhoea. To investigate the possible aetiological role of P. aeruginosa, these patient histories were reviewed and a selection of their faecal isolates were investigated in vitro (n ≤ 10) and in vivo (n = 2) for virulence. The patients had a mean age of 60 years, were receiving antibiotics and/or had an underlying illness. Extensive microbiological investigations identified no other potential or recognized enteropathogen in the faeces of 20 of these patients. More than 40% of the isolates tested were able to adhere to HEp-2 cells and exhibited twitching motility (type IV pili), properties indicative of their ability to colonize the human intestine. Cytotoxic activity was demonstrated in bacterium-free cell supernatants of over 80% of isolates; supernatants of four isolates tested in infant mice were weakly enterotoxigenic. Two isolates intragastrically inoculated into clindamycin pre-treated rats established persistent infections and induced signs and symptoms of enteritis. Overall these findings suggest that P. aeruginosa can cause diarrhoea particularly in immunodeficient individuals.

Item Details

Item Type:Refereed Article
Research Division:Biological Sciences
Research Group:Microbiology
Research Field:Bacteriology
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Environmental Sciences
Author:Adlard, PA (Dr Paul Anthony Adlard)
Author:Kirov, SM (Associate Professor Sylvia Kirov)
Author:Sanderson, K (Dr Kevin Sanderson)
Author:Cox, GE (Dr Erika Cox)
ID Code:14636
Year Published:1998
Web of Science® Times Cited:16
Deposited By:Pathology
Deposited On:1998-08-01
Last Modified:2011-08-09
Downloads:0

Repository Staff Only: item control page