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Maternal vaccination and infant influenza and pertussis


Rowe, SL and Leder, K and Perrett, KP and Romero, N and Nolan, TM and Stephens, N and Cowie, BC and Cheng, AC, Maternal vaccination and infant influenza and pertussis, Pediatrics, 148, (3) Article e2021051076. ISSN 0031-4005 (2021) [Refereed Article]

Copyright Statement

Copyright 2021 by the American Academy of Pediatrics

DOI: doi:10.1542/peds.2021-051076


Background and objectives: Infant influenza and pertussis disease causes considerable morbidity and mortality worldwide. We examined the effectiveness of maternal influenza and pertussis vaccines in preventing these diseases in infants.

Methods: This inception cohort study comprised women whose pregnancies ended between September 1, 2015, and December 31, 2017, in Victoria, Australia. Maternal vaccination status was sourced from the Victorian Perinatal Data Collection and linked to 5 data sets to ascertain infant outcomes and vaccination. The primary outcome of interest was laboratory-confirmed influenza or pertussis disease in infants aged <2 months, 2 to <6 months, and <6 months combined. Secondary outcomes included infant hospitalization (emergency presentation or admission) and death. Risk ratios and 95% confidence intervals (CIs) were estimated by Poisson regression. Vaccine effectiveness (VE) was estimated as (1 minus the risk ratio) x 100%.

Results: Among 186 962 pregnant women, 85 830 (45.9%) and 128 060 (68.5%) were vaccinated against influenza and pertussis, respectively. There were 175 and 51 infants with laboratory-confirmed influenza and pertussis disease, respectively. Influenza VE was 56.1% (95% CI, 23.3% to 74.9%) for infants aged <2 months and 35.7% (2.2% to 57.7%) for infants aged 2 to <6 months. Pertussis VE was 80.1% (95% CI, 37.1% to 93.7%) for infants aged <2 months and 31.8% (95% CI, -39.1% to 66.6%) for infants aged 2 to <6 months.

Conclusions: Our study provides evidence of the direct effectiveness of maternal influenza and pertussis vaccination in preventing these diseases in infants aged <2 months. The findings strengthen the importance of maternal vaccination to prevent these diseases in infants.

Item Details

Item Type:Refereed Article
Keywords:infant influenza, infant pertussis, maternal vaccination
Research Division:Health Sciences
Research Group:Epidemiology
Research Field:Behavioural epidemiology
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Public health (excl. specific population health) not elsewhere classified
UTAS Author:Stephens, N (Dr Nicola Stephens)
ID Code:146295
Year Published:2021
Web of Science® Times Cited:2
Deposited By:Medicine
Deposited On:2021-08-27
Last Modified:2021-12-24

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