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Pathogenic or protective? Neuropeptide Y in amyotrophic lateral sclerosis


Clark, CM and Clark, RM and Hoyle, JA and Dickson, TC, Pathogenic or protective? Neuropeptide Y in amyotrophic lateral sclerosis, Journal of Neurochemistry, 156, (3) pp. 273-289. ISSN 0022-3042 (2021) [Refereed Article]

Copyright Statement

2020 International Society for Neurochemistry

DOI: doi:10.1111/jnc.15125


Neuropeptide Y (NPY) is an endogenous peptide of the central and enteric nervous systems which has gained significant interest as a potential neuroprotective agent for treatment of neurodegenerative disease. Amyotrophic lateral sclerosis (ALS) is an aggressive and fatal neurodegenerative disease characterized by motor deficits and motor neuron loss. In ALS, recent evidence from ALS patients and animal models has indicated that NPY may have a role in the disease pathogenesis. Increased NPY levels were found to correlate with disease progression in ALS patients. Similarly, NPY expression is increased in the motor cortex of ALS mice by end stages of the disease. Although the functional consequence of increased NPY levels in ALS is currently unknown, NPY has been shown to exert a diverse range of neuroprotective roles in other neurodegenerative diseases; through modulation of potassium channel activity, increased production of neurotrophins, inhibition of endoplasmic reticulum stress and autophagy, reduction of excitotoxicity, oxidative stress, neuroinflammation and hyperexcitability. Several of these mechanisms and signalling pathways are heavily implicated in the pathogenesis of ALS. Therefore, in this review, we discuss possible effects of NPY and NPY-receptor signalling in the ALS disease context, as determining NPY's contribution to, or impact on, ALS disease mechanisms will be essential for future studies investigating the NPY system as a therapeutic strategy in this devastating disease.

Item Details

Item Type:Refereed Article
Keywords:amyotrophic lateral sclerosis, interneurons, neurodegeneration, neuropeptide Y, neuroprotection
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Neurology and neuromuscular diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Treatment of human diseases and conditions
UTAS Author:Clark, CM (Miss Courtney Clark)
UTAS Author:Clark, RM (Dr Rosie Clark)
UTAS Author:Hoyle, JA (Mr Joshua Hoyle)
UTAS Author:Dickson, TC (Professor Tracey Dickson)
ID Code:146267
Year Published:2021
Web of Science® Times Cited:6
Deposited By:Menzies Institute for Medical Research
Deposited On:2021-08-26
Last Modified:2022-08-23

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