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Abnormal screens among nonmutation carriers in the High Risk Ontario Breast Screening Program


Castelo, M and Brown, Z and Schellenberg, AE and Mills, JK and Eisen, A and Muradali, D and Grunfeld, E and Scheer, AS, Abnormal screens among nonmutation carriers in the High Risk Ontario Breast Screening Program, Breast Journal, 27, (5) pp. 423-431. ISSN 1075-122X (2021) [Refereed Article]

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2021 Wiley Periodicals LLC

DOI: doi:10.1111/tbj.14185


Background: The Ontario Breast Screening Program was expanded in 2011 to offer annual MRI and mammography to women with high-risk genetic mutations (e.g., BRCA1/2) and women with strong family histories and ≥25% estimated lifetime risk of breast cancer. Data to support high-risk screening is less clear in the nonmutation carrier group, as MRI has lower specificity among this population. The potential unintended consequences may be considerable and need to be explored. We aimed to describe the frequency of abnormal screens and biopsies.

Methods: Demographic surveys and chart review consent were sent to a sample of 441 individuals enrolled in a high-risk screening program at two tertiary care hospitals in Toronto, Ontario. Retrospective cross-sectional chart review was undertaken for clinicopathologic data. The frequencies of abnormal screens and biopsies were calculated.

Results: One hundred sixty-nine nonmutation carriers were included. The majority were white, employed, and highly educated. The median International Breast Cancer Intervention Study lifetime risk of breast cancer was 28.0% (range 24.5%-89.0%). 108 individuals (64%) experienced at least 1 abnormal screen and 13 (8%) had 3 or more over a median 3 years of screening (range 1-6 years). Of 55 biopsies, 3 (5.5%) were malignant. The cancer detection rate was 8.4/1000 screens (95% CI 3.2-22.4).

Conclusions: An MRI-based screening program for nonmutation carriers was effective at diagnosing breast cancer. However, this population experienced a high rate of abnormal screens and intervention. Further research is needed to improve the performance of MRI-based screening in these women.

Item Details

Item Type:Refereed Article
Keywords:MRI, high risk, screening
Research Division:Biomedical and Clinical Sciences
Research Group:Oncology and carcinogenesis
Research Field:Cancer diagnosis
Objective Division:Health
Objective Group:Clinical health
Objective Field:Diagnosis of human diseases and conditions
UTAS Author:Mills, JK (Dr Jane Mills)
ID Code:146222
Year Published:2021
Web of Science® Times Cited:1
Deposited By:Medicine
Deposited On:2021-08-25
Last Modified:2021-09-28

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