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Combined chronic myeloid leukaemia and chronic lymphocytic leukaemia in five patients, including one with 17p deletion

Citation

Armarego, M and Gottlieb, D and Dunlop, L and Cooney, JP, Combined chronic myeloid leukaemia and chronic lymphocytic leukaemia in five patients, including one with 17p deletion, Internal Medicine Journal, 51, (4) pp. 580-584. ISSN 1444-0903 (2021) [Refereed Article]

Copyright Statement

2021 Royal Australasian College of Physicians

DOI: doi:10.1111/imj.15271

Abstract

We report a series of five Australian cases of chronic lymphocytic leukaemia (CLL) occurring concurrently with chronic myeloid leukaemia (CML). Patient management including therapies and response together with clinical progress was obtained from medical records and laboratory information systems. Prior to CML diagnosis, all five had a preceding diagnosis of CLL. Three had received prior fludarabine. All received tyrosine kinase inhibitors (TKI). None required subsequent therapy for CLL. One patient had 17p deletion CLL and another patient had normal CLL cytogenetics. All currently have satisfactory blood counts with quantitative polymerase chain reaction for CML showing molecular response. All remain alive. Thus, such cases can be successfully managed by treating each haematological disorder in the usual manner. The control achieved in CML with the TKI enables satisfactory marrow function to recover in patients with concomitant CLL. The role for allograft in patients with dual malignancies is uncertain and needs to be individualised depending on control of each malignancy.

Item Details

Item Type:Refereed Article
Keywords:CLL, CML, combined malignancies
Research Division:Biomedical and Clinical Sciences
Research Group:Oncology and carcinogenesis
Research Field:Cancer therapy (excl. chemotherapy and radiation therapy)
Objective Division:Health
Objective Group:Clinical health
Objective Field:Treatment of human diseases and conditions
UTAS Author:Armarego, M (Dr Michael Armarego)
ID Code:146155
Year Published:2021
Deposited By:Medicine
Deposited On:2021-08-23
Last Modified:2021-10-19
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